{"id":"W4401606523","doi":"10.1021/acsptsci.4c00336","title":"Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia","year":2024,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University of Alberta","funders":"Alex's Lemonade Stand Foundation for Childhood Cancer; Mitacs; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Edmonton Civic Employees Charitable Assistance Fund; University of Alberta","keywords":"STAT protein; Lymphoblastic Leukemia; Cancer research; Activator (genetics); Transcription (linguistics); Transducer; Leukemia; Chemistry; Medicine; Biology; Cell biology; Receptor; Immunology; Signal transduction; STAT3; Engineering; Biochemistry; Philosophy; Electrical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801326,0.0003546456,0.0001887242,0.0003600571,0.00009105776,0.0001874205,0.0001471533,0.0002168955,0.001391412],"category_scores_gemma":[0.00007424993,0.0001785518,0.0001627884,0.0001668246,0.0001405754,0.0001722645,0.0001348554,0.0003602851,0.0003386876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215708,"about_ca_system_score_gemma":0.0001878714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009123443,"about_ca_topic_score_gemma":0.001039275,"domain_scores_codex":[0.9998696,0.00001948436,0.00001229114,0.00003193099,0.00004687179,0.00001986159],"domain_scores_gemma":[0.9999567,0.00001245596,0.00001217831,0.000003530555,0.00000692899,0.000008178435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003765221,0.00000767385,0.00002478295,0.00001110154,0.000001005288,0.00001215599,0.000003598057,0.00004061608,0.9992905,0.00002255704,0.00001761069,0.0005307694],"study_design_scores_gemma":[0.000007568031,0.0001032853,0.0006838748,0.000001751897,0.000004629572,0.00003581155,0.000004831365,0.001270445,0.9973587,0.0000123154,0.0005153741,0.000001356895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746904,0.001661218,0.01872111,0.0001441568,0.00002421129,0.00009638843,0.0005065792,0.0004834714,0.00367254],"genre_scores_gemma":[0.9616464,0.001625459,0.02569086,0.00009736019,0.00001021215,0.000213164,0.0007902686,0.00007425246,0.009852038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391412,"threshold_uncertainty_score":0.004654706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050122232430068,"score_gpt":0.2810030518348885,"score_spread":0.2705018295105878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}