{"id":"W4401607155","doi":"10.1126/science.ado5719","title":"Compensatory mutations potentiate constructive neutral evolution by gene duplication","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"","keywords":"Gene duplication; Gene; Biology; Mutation; Genetics; Function (biology); Functional divergence; Mutant; Computational biology; Gene family; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227161,0.0006151789,0.0006102162,0.0008119611,0.0003881012,0.0007357551,0.000668301,0.0007176155,0.001766126],"category_scores_gemma":[0.002362361,0.0003349954,0.0003954089,0.0004195901,0.00113523,0.0006853852,0.001863833,0.0009127863,0.0003337996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005784822,"about_ca_system_score_gemma":0.000385405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001453148,"about_ca_topic_score_gemma":0.0003317736,"domain_scores_codex":[0.9990677,0.0002527191,0.0000691415,0.0001554496,0.0003150499,0.0001399134],"domain_scores_gemma":[0.9985071,0.0006173962,0.0002785939,0.0002524853,0.0001504342,0.0001939017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003331329,0.00007608173,0.008967057,0.0001334615,0.00009622652,0.001226013,0.0001881686,0.001706364,0.9721655,0.004193811,0.0001187566,0.01079548],"study_design_scores_gemma":[0.0001875065,0.001421207,0.07751852,0.00009331312,0.0004087107,0.01051948,0.0006101544,0.03863929,0.8431515,0.01494065,0.0123325,0.0001772605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901128,0.0002778423,0.00597643,0.0001303021,0.00002147688,0.00003271091,0.00005025241,0.000118593,0.003279638],"genre_scores_gemma":[0.9968283,0.0001692905,0.002213547,0.00009547389,0.00001016669,0.00002208166,0.00004369796,0.00003556633,0.000581889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766126,"threshold_uncertainty_score":0.006489873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005899885038191656,"score_gpt":0.2404319618064236,"score_spread":0.2345320767682319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}