{"id":"W4401611824","doi":"10.3390/microorganisms12081682","title":"Antimicrobial Peptide Identified via Machine Learning Presents Both Potent Antibacterial Properties and Low Toxicity toward Human Cells","year":2024,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"West Virginia University; University of Nebraska Medical Center","keywords":"Antibiotics; Antimicrobial; Antimicrobial peptides; Fusidic acid; Toxicity; Gentamicin; Bacteria; Cytotoxicity; Microbiology; Staphylococcus aureus; Cefazolin; Biology; In vitro; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002438925,0.0004638242,0.0005227634,0.0001782709,0.0006418845,0.0004403019,0.0002998686,0.0003358562,0.0006565854],"category_scores_gemma":[0.00001498645,0.0004024231,0.0001758081,0.0001366277,0.000513404,0.0003723385,0.0004337052,0.0006738945,0.000583981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006584483,"about_ca_system_score_gemma":0.00006179565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006800591,"about_ca_topic_score_gemma":0.00005892906,"domain_scores_codex":[0.9978358,0.0002089717,0.000475485,0.0007388683,0.00006444167,0.0006764377],"domain_scores_gemma":[0.9994958,0.00003765946,0.0001174865,0.0002460357,0.000049008,0.0000540319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060125,0.00014593,0.0002834851,0.0003084296,0.0002327464,0.00005341459,0.001406063,0.000006252316,0.9911762,0.00004695986,0.005332008,0.000902469],"study_design_scores_gemma":[0.0007552422,0.0001563056,0.0006689634,0.0002734096,0.00009541461,0.0002745406,0.0001626898,0.00002110771,0.9887616,0.00003923595,0.008293359,0.000498125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942996,0.001823801,0.000532441,0.0002938853,0.00191846,0.0004089056,0.0001391009,0.0003815802,0.0002022552],"genre_scores_gemma":[0.9846053,0.0002194878,0.0001216072,0.0001852846,0.0002243167,0.000005944547,0.0002369795,0.00009401361,0.01430703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01410478,"threshold_uncertainty_score":0.9998428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157082108494558,"score_gpt":0.2126287474096701,"score_spread":0.1969205365602143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}