{"id":"W4401611824","doi":"10.3390/microorganisms12081682","title":"Antimicrobial Peptide Identified via Machine Learning Presents Both Potent Antibacterial Properties and Low Toxicity toward Human Cells","year":2024,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"West Virginia University; University of Nebraska Medical Center","keywords":"Antibiotics; Antimicrobial; Antimicrobial peptides; Fusidic acid; Toxicity; Gentamicin; Bacteria; Cytotoxicity; Microbiology; Staphylococcus aureus; Cefazolin; Biology; In vitro; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977983,0.0003731041,0.0003859942,0.0003103627,0.0001234337,0.0005040654,0.0001701421,0.0004718778,0.0007410728],"category_scores_gemma":[0.0005639808,0.00008111788,0.0002964852,0.0003251735,0.0002346375,0.0004498711,0.0002226404,0.0005491344,0.0004468722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421219,"about_ca_system_score_gemma":0.0001963552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007388484,"about_ca_topic_score_gemma":0.0001219529,"domain_scores_codex":[0.9998422,0.00003412071,0.00001466495,0.00003923803,0.00005110294,0.00001869889],"domain_scores_gemma":[0.999782,0.00006284773,0.00008694411,0.00001475719,0.00003976554,0.00001365908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002763801,0.0002600593,0.005130463,0.0007678441,0.0000683535,0.000288696,0.00003285789,0.008287359,0.7662002,0.001168901,0.0007117119,0.2168072],"study_design_scores_gemma":[0.00006544751,0.002604308,0.01088014,0.0001834693,0.0001114762,0.002261497,0.0001060873,0.06973615,0.8895296,0.003138809,0.02130884,0.00007431786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7505302,0.02524956,0.2098414,0.001243197,0.000346317,0.0002341416,0.0007412659,0.0005189549,0.01129507],"genre_scores_gemma":[0.8732765,0.01008119,0.1121403,0.0004324535,0.000173658,0.0001921912,0.0006503191,0.00002417681,0.00302937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007410728,"threshold_uncertainty_score":0.002479136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157082108494558,"score_gpt":0.2126287474096701,"score_spread":0.1969205365602143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}