{"id":"W4401623082","doi":"10.3389/fcell.2024.1458895","title":"Regulation of biological processes by ubiquitin ligases: a focus on the Pagano Lab’s contribution","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; Lawson Health Research Institute","funders":"Medicinska Fakulteten, Lunds Universitet; Lunds Universitet; Stiftelsen för Strategisk Forskning; Cancerfonden; Vetenskapsrådet; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ubiquitin; Ubiquitin ligase; Ubiquitin-conjugating enzyme; Proteolysis; Deubiquitinating enzyme; Proteasome; F-box protein; Biology; Cell biology; Ubiquitin-Protein Ligases; Ubiquitins; Protein degradation; Biochemistry; Signal transduction; Lysine; Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002890569,0.001194477,0.0008722541,0.001603924,0.0008125404,0.002747638,0.0006351967,0.002877698,0.002426079],"category_scores_gemma":[0.001635956,0.0003603813,0.0006211702,0.0006594776,0.002154364,0.002515009,0.002302046,0.006322058,0.001433699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00188524,"about_ca_system_score_gemma":0.001674531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006077399,"about_ca_topic_score_gemma":0.0005669627,"domain_scores_codex":[0.999001,0.0002538002,0.00004843575,0.0002733364,0.0002275263,0.0001958125],"domain_scores_gemma":[0.9985947,0.0002684024,0.00005663796,0.00009581179,0.0004425588,0.0005418637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000765321,0.0003388471,0.002248184,0.001150765,0.000104625,0.0008303184,0.0006381383,0.0006350052,0.01742285,0.0809451,0.5675935,0.3273274],"study_design_scores_gemma":[0.00009024712,0.000217854,0.001708787,0.0004314079,0.00005292428,0.0009102215,0.0001769503,0.0004443572,0.004005189,0.02327961,0.9686298,0.00005268447],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01206446,0.5765234,0.004373219,0.3280069,0.05696962,0.00004257694,0.0001232007,0.0001558767,0.02174069],"genre_scores_gemma":[0.1327987,0.5182065,0.005929221,0.1316665,0.1472091,0.0001231897,0.000205807,0.0002488492,0.06361202],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002890569,"threshold_uncertainty_score":0.01528698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018979214629551,"score_gpt":0.220222324289856,"score_spread":0.2100325321435605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}