{"id":"W4401627167","doi":"10.1111/bcp.16203","title":"Evaluating the evidence for genotype‐informed Bayesian dosing of tacrolimus in children undergoing solid organ transplantation: A systematic literature review","year":2024,"lang":"en","type":"review","venue":"British Journal of Clinical Pharmacology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; National Health and Medical Research Council; State Government of Victoria; Children's Hospital Foundation; Royal Children's Hospital Foundation; Murdoch Children's Research Institute; University of Melbourne; Medical Research Council; Novo Nordisk; Children’s Hospital of Wisconsin Research Institute","keywords":"Dosing; Tacrolimus; Medicine; Therapeutic drug monitoring; Transplantation; Calcineurin; Organ transplantation; Intensive care medicine; Pharmacokinetics; Therapeutic index; Pharmacology; Internal medicine; Drug","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01216094,0.00155279,0.008954789,0.01016938,0.0004803309,0.003116048,0.002678819,0.002318853,0.007621152],"category_scores_gemma":[0.07388587,0.001163343,0.01054793,0.00858583,0.0008332752,0.002410412,0.001663415,0.001766097,0.0005971128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003988242,"about_ca_system_score_gemma":0.01332006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009848823,"about_ca_topic_score_gemma":0.02253261,"domain_scores_codex":[0.9899724,0.004086087,0.003837712,0.0005832511,0.001334674,0.0001860306],"domain_scores_gemma":[0.9303651,0.05728629,0.007839788,0.000650467,0.003478783,0.0003796243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002049372,0.00001328251,0.0004499214,0.9544492,0.009529529,0.00005818815,0.0001057186,0.0001664436,0.00007010924,0.0002256621,0.0008479696,0.03387918],"study_design_scores_gemma":[0.0002499764,0.0001330495,0.00142964,0.9287922,0.0583948,0.0001560792,0.0001409179,0.0001255846,0.00008432652,0.0002965608,0.01016897,0.00002793384],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008708902,0.997051,0.0003663874,0.0003880136,0.0001111168,0.0003454934,0.0005241637,0.00001175395,0.0003311357],"genre_scores_gemma":[0.01301175,0.9841336,0.001131316,0.0006843795,0.00007994784,0.0005350439,0.0003292433,0.00001037305,0.00008436834],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01216094,"threshold_uncertainty_score":0.06431395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.204021154463395,"score_gpt":0.5684133473636991,"score_spread":0.3643921929003041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}