{"id":"W4401628302","doi":"10.1096/fj.202400867r","title":"Diverse biophysical mechanisms in voltage‐gated sodium channel Na <sub>v</sub> 1.4 variants associated with myotonia","year":2024,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Russian Science Foundation; KU Leuven","keywords":"Myotonia; Sodium channel; Xenopus; Mutant; Voltage clamp; Mutation; Biophysics; Population; Biology; Chemistry; Genetics; Medicine; Membrane potential; Gene; Sodium; Myotonic dystrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914981,0.0004819613,0.0002448189,0.0002422947,0.0001343175,0.0001743206,0.0002012602,0.0004144228,0.0006156109],"category_scores_gemma":[0.0003241737,0.0001393828,0.0002869074,0.0001456837,0.0003869333,0.000139807,0.0002278166,0.0002481397,0.0001496796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00015883,"about_ca_system_score_gemma":0.00006528453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005192838,"about_ca_topic_score_gemma":0.0005107385,"domain_scores_codex":[0.9998572,0.00003401939,0.00002086294,0.00002959599,0.00003531545,0.00002303163],"domain_scores_gemma":[0.9998158,0.00006514585,0.00006307213,0.00001335944,0.00001294417,0.00002968341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004409061,0.00003663641,0.01766719,0.00003598885,0.00004019857,0.005590427,0.0001350061,0.0004518606,0.9739758,0.0001699125,0.00005356608,0.001402645],"study_design_scores_gemma":[0.0001442596,0.001629097,0.4077801,0.00002792485,0.0002338121,0.05400485,0.0003564727,0.009685548,0.5239068,0.0007215458,0.001457424,0.0000522107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999203,0.0001047703,0.0004027339,0.000020583,0.000003608061,0.000004798909,0.00004618533,0.00001064019,0.0002037386],"genre_scores_gemma":[0.9996411,0.00003715634,0.0001871722,0.00001588594,0.000002376155,0.000003418121,0.0000449949,0.000005366838,0.00006260605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006156109,"threshold_uncertainty_score":0.0020594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097694736899376,"score_gpt":0.2161150516612556,"score_spread":0.2051381042922618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}