{"id":"W4401631051","doi":"10.21203/rs.3.rs-4608404/v1","title":"Targeting LMO2-induced autocrine FLT3 signalling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"Cancer research; Autocrine signalling; Stem cell; Biology; Progenitor cell; Cytokine; Immunology; Cell biology; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386882,0.0001810025,0.0002274225,0.0001535668,0.0001240495,0.0004826541,0.0001940858,0.0002206838,0.002251284],"category_scores_gemma":[0.0001196011,0.00008098794,0.0001499362,0.0001440292,0.0001565238,0.0002057475,0.000267908,0.0007385194,0.0004310713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005066296,"about_ca_system_score_gemma":0.0003497872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007555168,"about_ca_topic_score_gemma":0.001472034,"domain_scores_codex":[0.9999183,0.00001062214,0.000002337393,0.00001068895,0.00002162471,0.00003634386],"domain_scores_gemma":[0.9999741,0.000003950416,0.000005966549,0.000003196494,0.000003399793,0.000009266217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007700385,0.0001683063,0.0004528941,0.000157434,0.00001947555,0.0001251776,0.00004240254,0.0009433203,0.9736773,0.001184297,0.002125094,0.02033424],"study_design_scores_gemma":[0.0004466144,0.0008669065,0.003315687,0.0000200858,0.00005786428,0.0003973903,0.0000692949,0.00624351,0.9532142,0.000767239,0.03458563,0.00001563139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977518,0.004937526,0.00658643,0.001438401,0.0002334541,0.00008640792,0.0009007734,0.0006393017,0.007659755],"genre_scores_gemma":[0.991013,0.00120517,0.002330455,0.0001470315,0.00003527612,0.00005549215,0.0004832024,0.00006980364,0.004660478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002251284,"threshold_uncertainty_score":0.007531345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03523846910033718,"score_gpt":0.3593624795858788,"score_spread":0.3241240104855416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}