{"id":"W4401637350","doi":"10.1016/j.immuni.2024.07.021","title":"BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"H2020 European Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Research Computing Center, University of Chicago; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Engineering Research Centers; National Institutes of Health, Pakistan; University of Chicago","keywords":"Biology; Innate immune system; Epigenetics; Progenitor cell; Immunology; Vaccination; Bone marrow; Immune system; Progenitor; Immunity; Cell biology; Stem cell; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546078,0.00008940738,0.0001910329,0.0001602552,0.0001263854,0.0003381509,0.0001011792,0.0001714894,0.002358554],"category_scores_gemma":[0.0002137503,0.000120188,0.0001072293,0.0001066431,0.0001346087,0.00010825,0.0001790319,0.0004078294,0.000411853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248894,"about_ca_system_score_gemma":0.0001629701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000512358,"about_ca_topic_score_gemma":0.0007837531,"domain_scores_codex":[0.9998963,0.00002465667,0.000004774916,0.00002151865,0.00002262531,0.00003014753],"domain_scores_gemma":[0.9999442,0.00001490304,0.00001247767,0.000007135868,0.000008853434,0.00001236052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005471652,0.00005041364,0.004351736,0.00004017192,0.00001398512,0.00005725933,0.00008731939,0.0001360599,0.9857993,0.0003091546,0.0001374381,0.00847004],"study_design_scores_gemma":[0.0000954131,0.001647538,0.1988225,0.00006448577,0.0001194748,0.0007261398,0.0006620468,0.001947314,0.7829466,0.0006556524,0.01229698,0.00001584998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931932,0.003535993,0.001691652,0.0001052819,0.00004182952,0.00001431111,0.0001627672,0.0000353573,0.001219594],"genre_scores_gemma":[0.9979568,0.0005194886,0.0002909898,0.00007230893,0.00001003763,0.00001351338,0.0001200205,0.00001010777,0.001006798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358554,"threshold_uncertainty_score":0.007890165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220167624557736,"score_gpt":0.2809603465224653,"score_spread":0.2687586702768879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}