{"id":"W4401637350","doi":"10.1016/j.immuni.2024.07.021","title":"BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"H2020 European Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Research Computing Center, University of Chicago; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Engineering Research Centers; National Institutes of Health, Pakistan; University of Chicago","keywords":"Biology; Innate immune system; Epigenetics; Progenitor cell; Immunology; Vaccination; Bone marrow; Immune system; Progenitor; Immunity; Cell biology; Stem cell; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083277,0.0001785096,0.0002596108,0.0004414597,0.0002823261,0.00004299558,0.0004353603,0.0001506153,0.0003943711],"category_scores_gemma":[0.0002515014,0.0001387351,0.0001090758,0.0005456751,0.00006875444,0.0001277664,0.0002029463,0.0004695135,0.0002176254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006339401,"about_ca_system_score_gemma":0.0001225216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008278258,"about_ca_topic_score_gemma":0.0001426441,"domain_scores_codex":[0.9980195,0.0008542966,0.0005336557,0.0002145248,0.00005672338,0.0003212993],"domain_scores_gemma":[0.9986578,0.0005481749,0.00009960977,0.0005484155,0.0001294787,0.00001652973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003429533,0.0001191145,0.00119109,0.00005519893,0.00007497729,0.000007017324,0.002233121,0.00009078231,0.9875638,0.0003547474,0.000291235,0.00767589],"study_design_scores_gemma":[0.0006408375,0.000290307,0.342726,0.0001409541,0.00003750602,0.00003303371,0.0006477807,0.0000248641,0.6482802,0.0001640413,0.0068208,0.0001936248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987248,0.01063521,0.00003196409,0.000760447,0.0004617988,0.0005501853,0.00004773255,0.00006065193,0.0002039864],"genre_scores_gemma":[0.9970359,0.0001481298,0.00002996302,0.00005222061,0.00001269045,0.00008927906,0.00004000827,0.00002144307,0.002570318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3415349,"threshold_uncertainty_score":0.5657454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220167624557736,"score_gpt":0.2809603465224653,"score_spread":0.2687586702768879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}