{"id":"W4401642841","doi":"10.1590/1984-3143-ar2024-0030","title":"Haploid embryos and embryonic stem cells to produce offspring with predetermined parental genomes in cattle","year":2024,"lang":"en","type":"article","venue":"Animal Reproduction","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Agencia Nacional de Investigación y Desarrollo; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Offspring; Embryonic stem cell; Embryo; Ploidy; Genome; Genetics; Stem cell; Andrology; Embryogenesis; Cell biology; Gene; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025465,0.0001793386,0.000135895,0.0001051066,0.00006871672,0.00007202228,0.00007726304,0.00007761044,0.000003964547],"category_scores_gemma":[0.00001502272,0.0001551377,0.00003435305,0.0002233643,0.00005563242,0.00001454914,0.0001001513,0.0001076029,0.00001745573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003383624,"about_ca_system_score_gemma":0.0000665214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003393185,"about_ca_topic_score_gemma":0.00006111602,"domain_scores_codex":[0.9981808,0.00003017341,0.0001862998,0.001231283,0.0001290079,0.0002424146],"domain_scores_gemma":[0.9994174,0.000003147366,0.00003743344,0.0004133401,0.00005617872,0.00007252824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002783782,0.00004258329,0.003406953,0.00008404641,0.00002820027,0.000006616302,0.0002143583,0.0002776491,0.9811003,0.00001761031,0.0002830051,0.01426029],"study_design_scores_gemma":[0.000169322,0.00159709,0.03227669,0.00005938731,0.00002599579,0.0001598183,0.0002547749,0.0001176447,0.9403299,0.000007246256,0.02472417,0.0002779382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934868,0.004899299,0.00008336839,0.000562347,0.0003510322,0.0004582385,0.000004719201,0.00004155634,0.000112642],"genre_scores_gemma":[0.9947578,0.000404494,0.0003348703,0.00002098012,0.0007724757,0.00005165361,0.00001230907,0.00004048816,0.003604947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04077039,"threshold_uncertainty_score":0.6326334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014778096159051,"score_gpt":0.2335602228191794,"score_spread":0.2234124418575889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}