{"id":"W4401642841","doi":"10.1590/1984-3143-ar2024-0030","title":"Haploid embryos and embryonic stem cells to produce offspring with predetermined parental genomes in cattle","year":2024,"lang":"en","type":"article","venue":"Animal Reproduction","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Agencia Nacional de Investigación y Desarrollo; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Offspring; Embryonic stem cell; Embryo; Ploidy; Genome; Genetics; Stem cell; Andrology; Embryogenesis; Cell biology; Gene; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001187505,0.0002370417,0.0003691502,0.0007989389,0.0004766427,0.0007774741,0.0007558492,0.0005824965,0.003711445],"category_scores_gemma":[0.000442451,0.0004084852,0.0003253043,0.0005665867,0.0005612329,0.0003736535,0.0005081458,0.0007775586,0.001063763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008179885,"about_ca_system_score_gemma":0.0004738211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002465546,"about_ca_topic_score_gemma":0.00396859,"domain_scores_codex":[0.9996295,0.0001272416,0.00003692098,0.00006311657,0.000094954,0.00004816414],"domain_scores_gemma":[0.9998031,0.0000880797,0.00002588309,0.00003182257,0.00001408391,0.00003709976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003287596,0.00009200804,0.002558262,0.000316061,0.00003619759,0.0005187856,0.0003365773,0.001558117,0.9546281,0.005789617,0.0005189066,0.03331864],"study_design_scores_gemma":[0.0001849674,0.0008981377,0.02516405,0.00018348,0.0001504403,0.002480855,0.0004480681,0.005602254,0.8666248,0.003356427,0.09484012,0.00006641265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8503013,0.01266614,0.1014693,0.0008709317,0.0002208692,0.0005012061,0.002610199,0.0006977894,0.03066218],"genre_scores_gemma":[0.8702958,0.008843238,0.08374447,0.0002922406,0.00003881642,0.00035265,0.003455978,0.0003026702,0.03267404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003711445,"threshold_uncertainty_score":0.01241601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014778096159051,"score_gpt":0.2335602228191794,"score_spread":0.2234124418575889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}