{"id":"W4401652194","doi":"10.1101/2024.08.15.608064","title":"Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Medical Research Council; National Institutes of Health","keywords":"Death-associated protein 6; Biology; Histone; Chromatin; Genome; Histone H3; Lytic cycle; DNA replication; Genetics; Cell biology; DNA; Transcription factor; Virus; Gene; Nuclear protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008443621,0.0001686413,0.0001610521,0.00009666176,0.0001402046,0.0003408107,0.0001765264,0.0001268758,0.0007958144],"category_scores_gemma":[0.0000809512,0.0001267123,0.0001709127,0.00008811308,0.0002152657,0.0001735473,0.0002579867,0.0003802304,0.0003045785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549075,"about_ca_system_score_gemma":0.0002592799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001424943,"about_ca_topic_score_gemma":0.001762759,"domain_scores_codex":[0.9999099,0.000005450376,0.000004784462,0.00002734923,0.00002607291,0.00002647749],"domain_scores_gemma":[0.9999372,0.000008992732,0.00001865304,0.000009660876,0.000008220924,0.00001740468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003418669,0.000003437128,0.0002075462,0.000009852716,0.00000134317,0.000008997639,0.000009297368,0.00002788169,0.9991622,0.00004768483,0.000008910284,0.0004787393],"study_design_scores_gemma":[0.000001785913,0.00004290531,0.003392612,0.000001701519,0.000002529757,0.00006559165,0.00001573892,0.0004121527,0.9953207,0.00002251711,0.000720335,0.000001405899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933689,0.0007789868,0.004358868,0.00002735975,0.00001306425,0.00001014722,0.0002115663,0.00007544347,0.001155686],"genre_scores_gemma":[0.9940317,0.0005005419,0.002891696,0.00002454773,0.00000405741,0.00001231611,0.0003150364,0.00002717671,0.002192889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424943,"threshold_uncertainty_score":0.002833366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373939795033358,"score_gpt":0.2624903677240964,"score_spread":0.2487509697737628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}