{"id":"W4401656522","doi":"10.1002/ajh.27459","title":"Intra‐tumoral and peripheral blood <scp>TIGIT</scp> and <scp>PD</scp>‐1 as immune biomarkers in nodular lymphocyte predominant Hodgkin lymphoma","year":2024,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; Astellas Pharma; Irish Research Council; University of Queensland; National Cancer Institute; National Research Foundation; Cancer Australia; Leukaemia Foundation; EUSA Pharma; Mater Foundation; National Research Foundation Singapore; Gilead Sciences; Regeneron Pharmaceuticals; Leukemia and Lymphoma Society; BeiGene; Daiichi Sankyo Europe; Sanofi; Amgen; American Association for Cancer Research; Bristol-Myers Squibb; National Health and Medical Research Council; American Society of Hematology","keywords":"TIGIT; CD8; Immune system; Cancer research; Lymphoma; Immunophenotyping; Biology; Hodgkin's lymphoma; T cell; Lymphocyte; Immunology; Tumor microenvironment; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004634033,0.0002075302,0.0002293287,0.0008335662,0.00009679192,0.0005877098,0.000110503,0.0002098917,0.0002977333],"category_scores_gemma":[0.0003723906,0.0001309027,0.0001439598,0.0003758262,0.0002659804,0.0001932557,0.0003031201,0.0002885767,0.00008146275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155968,"about_ca_system_score_gemma":0.00009390042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004760496,"about_ca_topic_score_gemma":0.0004964226,"domain_scores_codex":[0.9998253,0.00005088416,0.000008471994,0.00004748166,0.00004045877,0.00002745185],"domain_scores_gemma":[0.9998351,0.00004547633,0.00005522403,0.00001394337,0.00002089338,0.00002935685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00244229,0.0001236282,0.4277365,0.0001000033,0.0001806552,0.0003152044,0.0002569419,0.001506136,0.5308632,0.0001674966,0.00021695,0.03609105],"study_design_scores_gemma":[0.00002904472,0.0008470058,0.9212471,0.00001935875,0.0001611844,0.001245604,0.0002906654,0.009478872,0.06478202,0.0003222824,0.001561429,0.00001543951],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988006,0.0004865876,0.0003834073,0.00001171195,0.000001999216,0.00000639355,0.00009674209,0.00001046678,0.0002019488],"genre_scores_gemma":[0.998827,0.0001409387,0.0006305256,0.0000207824,0.000004779495,0.00001248046,0.0002109123,0.000003200751,0.0001492539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008335662,"threshold_uncertainty_score":0.002450705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005422366018276542,"score_gpt":0.2456751197029753,"score_spread":0.2402527536846988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}