{"id":"W4401660144","doi":"10.1016/j.euf.2024.07.015","title":"Should Only Patients with BRCA Mutation Be Treated with a Combination of an Androgen Receptor Pathway Inhibitor and a PARP Inhibitor for Metastatic Castration-resistant Prostate Cancer? The Answer Is No","year":2024,"lang":"en","type":"article","venue":"European Urology Focus","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; PARP inhibitor; Prostate cancer; Androgen receptor; Oncology; Internal medicine; Cancer research; Poly ADP ribose polymerase; Castration; Prostate; Cancer; Gene; Hormone; Polymerase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004200205,0.0004334916,0.003178742,0.0004266509,0.0009754025,0.002014527,0.001503468,0.007833306,0.009147679],"category_scores_gemma":[0.01759455,0.0004280058,0.001198704,0.0006485438,0.00154313,0.005883798,0.0007672972,0.009778587,0.004447146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00085231,"about_ca_system_score_gemma":0.00259862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00297723,"about_ca_topic_score_gemma":0.008066477,"domain_scores_codex":[0.9985103,0.0004598397,0.0002923527,0.0002851898,0.0002922947,0.0001599921],"domain_scores_gemma":[0.9841338,0.01022105,0.001405495,0.0003295886,0.002494762,0.001415262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005280459,0.001077414,0.01927081,0.004232624,0.00123093,0.001149177,0.0002540676,0.001227967,0.003404372,0.008277715,0.3456826,0.6089119],"study_design_scores_gemma":[0.006455335,0.002689175,0.07402836,0.0128454,0.003099644,0.005057229,0.004261616,0.002212906,0.001555957,0.07583936,0.8114523,0.0005026822],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00746451,0.1333329,0.001550628,0.8415345,0.009318508,0.00004602853,0.0004804943,0.00008708439,0.006185428],"genre_scores_gemma":[0.09928431,0.1668165,0.007749899,0.6337134,0.08489935,0.000200672,0.001149363,0.0001260736,0.006060357],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009147679,"threshold_uncertainty_score":0.03060204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205771521350204,"score_gpt":0.280704198087813,"score_spread":0.258646482874311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}