{"id":"W4401660144","doi":"10.1016/j.euf.2024.07.015","title":"Should Only Patients with BRCA Mutation Be Treated with a Combination of an Androgen Receptor Pathway Inhibitor and a PARP Inhibitor for Metastatic Castration-resistant Prostate Cancer? The Answer Is No","year":2024,"lang":"en","type":"article","venue":"European Urology Focus","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; PARP inhibitor; Prostate cancer; Androgen receptor; Oncology; Internal medicine; Cancer research; Poly ADP ribose polymerase; Castration; Prostate; Cancer; Gene; Hormone; Polymerase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945485,0.0002192889,0.0002612347,0.0001356082,0.0001404102,0.00005714509,0.00006122482,0.00004092154,0.00003908149],"category_scores_gemma":[0.00002984289,0.0001186917,0.00004109715,0.0002453861,0.0002655016,0.0001819487,0.00002001488,0.0001701089,0.00000657174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007052212,"about_ca_system_score_gemma":0.0002987074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008681138,"about_ca_topic_score_gemma":0.0001581721,"domain_scores_codex":[0.9984875,0.0002292077,0.0002925651,0.0004223046,0.0003003183,0.0002681182],"domain_scores_gemma":[0.9990348,0.0001117093,0.0001203957,0.0001980358,0.0004197125,0.0001153551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1713758,0.008122405,0.2153739,0.0048387,0.00932235,0.003042502,0.06239102,0.0001359902,0.1025142,0.001571324,0.01594638,0.4053655],"study_design_scores_gemma":[0.1239515,0.2160359,0.3176125,0.002115707,0.006764647,0.0004793334,0.003019388,0.006508788,0.2283141,0.0004658549,0.09228706,0.002445178],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928733,0.001086088,0.00002788008,0.002765228,0.0000835839,0.00215614,0.0006969962,0.0000584818,0.0002523178],"genre_scores_gemma":[0.9979901,0.0000617052,0.0002688441,0.000194736,0.00008003103,0.0001755862,0.0005259331,0.00006662703,0.000636494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4029203,"threshold_uncertainty_score":0.4840108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205771521350204,"score_gpt":0.280704198087813,"score_spread":0.258646482874311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}