{"id":"W4401669823","doi":"10.1016/j.celrep.2024.114637","title":"Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal General Hospital; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of General Medical Sciences; Centre Azrieli de recherche sur l'autisme, Institut et Hôpital Neurologiques de Montréal; Hospital for Sick Children; National Institute of Mental Health; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Azrieli Foundation; Canadian Institutes of Health Research; National Institutes of Health; Canada First Research Excellence Fund; Montreal Neurological Institute and Hospital; National Alliance for Research on Schizophrenia and Depression; McGill University","keywords":"Neuroinflammation; Gliosis; Autism; Neuroscience; Chromatin remodeling; Microglia; Medicine; Chromatin; Astrocyte; Inflammation; Biology; Internal medicine; Central nervous system; Genetics; Psychiatry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009770506,0.0002069335,0.0001204832,0.0002355896,0.0001395182,0.0002154244,0.0001634695,0.0002078837,0.00111626],"category_scores_gemma":[0.0001504427,0.0001278317,0.0001232918,0.00005627564,0.0003252079,0.0001410819,0.0002905204,0.0002616315,0.0001783677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424773,"about_ca_system_score_gemma":0.0001603371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006390507,"about_ca_topic_score_gemma":0.001426881,"domain_scores_codex":[0.9998829,0.00001411526,0.00001156168,0.00003661025,0.00003033595,0.00002430846],"domain_scores_gemma":[0.9998891,0.00001267118,0.00004068621,0.00001169956,0.0000135554,0.00003218989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007776231,0.000006267711,0.0007173457,0.0000167991,0.0000030845,0.00007006257,0.0000263455,0.00003708861,0.997601,0.0001400806,0.00003528559,0.001268925],"study_design_scores_gemma":[0.00003136496,0.0001996227,0.03664375,0.00001155065,0.00002446727,0.0005863477,0.0001401274,0.001303362,0.9566655,0.0002704358,0.004114333,0.000009145489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928898,0.000806093,0.004541912,0.0001039318,0.00003142898,0.00001281643,0.0001983732,0.0001302053,0.001285355],"genre_scores_gemma":[0.9968304,0.0002715543,0.001254853,0.00002513744,0.000004878477,0.00001865758,0.0001294273,0.00001844999,0.001446632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111626,"threshold_uncertainty_score":0.003734231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004980141266945982,"score_gpt":0.2068217250374511,"score_spread":0.2018415837705051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}