{"id":"W4401677755","doi":"10.1016/j.celrep.2024.114649","title":"Optogenetic control of kinesin-1, -2, -3 and dynein reveals their specific roles in vesicular transport","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; McGill University","keywords":"Kinesin; Dynein; Endosome; Cell biology; Microtubule; Optogenetics; Motor protein; Dynactin; Biology; Vesicular transport protein; Endocytosis; Vesicle; Neuroscience; Biochemistry; Cell; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007674204,0.0002127709,0.0001112261,0.0001176887,0.0001428343,0.0003223234,0.0001907975,0.0001799494,0.0005948517],"category_scores_gemma":[0.00008321481,0.0001508619,0.000149473,0.0001066738,0.0002618341,0.0001717321,0.0001589971,0.0003957076,0.000122413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005563563,"about_ca_system_score_gemma":0.0004459382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729708,"about_ca_topic_score_gemma":0.00493866,"domain_scores_codex":[0.999944,0.000004635327,0.000004117652,0.00001451662,0.0000145864,0.00001812656],"domain_scores_gemma":[0.9999262,0.00001651028,0.00003048727,0.000006440114,0.000004836135,0.00001539566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006087988,0.000007628126,0.0001805677,0.000009058503,0.000001616698,0.00001353292,0.000005675455,0.0002036031,0.9983193,0.0004909182,0.00001201635,0.0006950861],"study_design_scores_gemma":[0.000009305019,0.00003945538,0.001881794,0.000002246165,0.000008362079,0.00006624751,0.00001164286,0.002189001,0.9943234,0.00007059399,0.001394165,0.000003642144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934964,0.0004370529,0.004345313,0.00007288696,0.00001456658,0.00001665087,0.0001400142,0.00003257193,0.001444498],"genre_scores_gemma":[0.9928967,0.0005475027,0.004342292,0.00003424559,0.000003452368,0.00002137592,0.00009436547,0.00001950499,0.002040566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729708,"threshold_uncertainty_score":0.004036605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004337743716881837,"score_gpt":0.1997705406409432,"score_spread":0.1954327969240613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}