{"id":"W4401687611","doi":"10.1101/2024.08.17.608386","title":"Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Esophageal adenocarcinoma; Adenocarcinoma; Medicine; Primary (astronomy); Pathology; Oncology; Primary tumor; Internal medicine; Metastasis; Cancer; Astronomy; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125931,0.00007865165,0.0002414433,0.000428362,0.0001834096,0.0004012318,0.00008479171,0.0002125124,0.001243355],"category_scores_gemma":[0.0002966156,0.0001227227,0.0001571218,0.0003533119,0.0001585305,0.0001318456,0.0002387711,0.0001806512,0.0003240241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586161,"about_ca_system_score_gemma":0.0001080618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070145,"about_ca_topic_score_gemma":0.002188435,"domain_scores_codex":[0.9999074,0.000008784279,0.000005945022,0.00003951695,0.00001588123,0.00002255363],"domain_scores_gemma":[0.9999031,0.00002810164,0.00002135619,0.00001057992,0.00001637067,0.00002060895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009453741,0.00004265845,0.2480463,0.0001270756,0.00008283117,0.0002876886,0.0005649409,0.001138295,0.7326765,0.0003885204,0.0007045687,0.01499515],"study_design_scores_gemma":[0.00001022923,0.00009461046,0.9567918,0.000009738559,0.00004641485,0.0005383167,0.000474914,0.002619474,0.03716559,0.0003344083,0.001902437,0.00001210912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968514,0.0003615376,0.0008271271,0.0000234124,0.0000040067,0.000006519861,0.001338356,0.00002674826,0.0005608649],"genre_scores_gemma":[0.9958208,0.0002154506,0.0008233678,0.0000322415,0.00000460026,0.00002653338,0.002429157,0.00002150852,0.0006262833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243355,"threshold_uncertainty_score":0.004159451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291104639912618,"score_gpt":0.2735377403514394,"score_spread":0.2506266939523132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}