{"id":"W4401687887","doi":"10.1101/2024.08.17.608401","title":"Circadian clock in the lateral habenula affects motor function in mice through the regulation of daily rhythms in the nigrostriatal pathway","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Circadian rhythm; Rhythm; Neuroscience; Circadian clock; Habenula; Motor function; Motor activity; Function (biology); Wheel running; Biology; Physical medicine and rehabilitation; Medicine; Internal medicine; Endocrinology; Central nervous system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003456229,0.0007413292,0.0003697651,0.001161929,0.0003670385,0.0005726885,0.0006582785,0.0008314708,0.003402776],"category_scores_gemma":[0.0001600031,0.0004167415,0.0004508998,0.0002447659,0.0009350913,0.0004467489,0.0004298548,0.001505425,0.0007360026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000762715,"about_ca_system_score_gemma":0.0004523766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001449265,"about_ca_topic_score_gemma":0.003346711,"domain_scores_codex":[0.9994802,0.00006822416,0.000052711,0.0001495531,0.0001320247,0.0001173981],"domain_scores_gemma":[0.9994191,0.00004199218,0.0002675982,0.00005414596,0.00003030595,0.0001868942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392265,0.00005796466,0.0001799357,0.00002072943,0.000006578836,0.00005710166,0.00002293928,0.00006288412,0.9984518,0.0002571383,0.00005082152,0.0006928457],"study_design_scores_gemma":[0.0000765956,0.0006245082,0.009076395,0.00003194883,0.00003498758,0.000235833,0.00008666027,0.001645185,0.9848558,0.0001775349,0.003141003,0.00001357322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871536,0.001083846,0.006629477,0.000530159,0.0001026998,0.00008025386,0.00162366,0.0006172552,0.002179084],"genre_scores_gemma":[0.9732592,0.0007677707,0.007666491,0.0002697424,0.00003455391,0.0002567076,0.001098395,0.0003552281,0.0162919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003402776,"threshold_uncertainty_score":0.01138341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820324831364551,"score_gpt":0.2217831331187148,"score_spread":0.2035798848050693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}