{"id":"W4401694572","doi":"10.1186/s13195-024-01555-z","title":"Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Health Research Board; Health Service Executive; Wellcome Trust; Meath Foundation; Canadian Institute for Theoretical Astrophysics","keywords":"Electrochemiluminescence; Immunoassay; Geriatric psychiatry; Medicine; Neurology; Cohort; Internal medicine; Oncology; Psychiatry; Chromatography; Chemistry; Immunology; Antibody; Detection limit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002588349,0.0001908539,0.0003807009,0.0003918208,0.0001766943,0.0000319918,0.0002674613,0.0001144315,0.00005593886],"category_scores_gemma":[0.00009806209,0.0001305814,0.0001874096,0.0009455241,0.0004752742,0.0002688298,0.00005437516,0.0005279418,0.00001031009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147672,"about_ca_system_score_gemma":0.0008185452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008024361,"about_ca_topic_score_gemma":0.00004732699,"domain_scores_codex":[0.9972748,0.0003180543,0.0004186781,0.0004328993,0.0009141137,0.0006414588],"domain_scores_gemma":[0.9976677,0.001005456,0.00006913699,0.0005877925,0.000508921,0.0001610255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01254781,0.001824747,0.03812809,0.0002838754,0.01664421,0.00005018527,0.000698376,0.00001555589,0.7679461,0.00001277983,0.00004794719,0.1618003],"study_design_scores_gemma":[0.002408102,0.00371331,0.05743512,0.0003199238,0.0004884158,0.00003876595,0.0002305358,0.03972878,0.8953266,0.00004714945,0.0001121168,0.0001512381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9332715,0.06409886,0.00005360534,0.0001200034,0.00006222057,0.002201738,0.00002157321,0.00002613774,0.0001443853],"genre_scores_gemma":[0.9919332,0.007407008,0.0001191167,0.00001383201,0.0000998824,0.0003285931,0.00002375998,0.00004553982,0.00002904727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1616491,"threshold_uncertainty_score":0.5324956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063641431821389,"score_gpt":0.4154275490915161,"score_spread":0.3090634059093772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}