{"id":"W4401695143","doi":"10.1136/ard-2024-225686","title":"Efficacy and safety of sequential therapy with subcutaneous belimumab and one cycle of rituximab in patients with systemic lupus erythematosus: the phase 3, randomised, placebo-controlled BLISS-BELIEVE study","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Medical Research Council","keywords":"Medicine; Belimumab; Rituximab; Placebo; Internal medicine; Adverse effect; Phases of clinical research; BLISS; Dermatology; Clinical trial; Immunology; Antibody; Alternative medicine; B-cell activating factor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004720123,0.002064744,0.003966226,0.0005098488,0.0004928349,0.001210939,0.001347981,0.002712586,0.005349128],"category_scores_gemma":[0.003435981,0.0009851158,0.003070951,0.0004644682,0.001714552,0.001652942,0.0005511254,0.003395187,0.00111677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009697437,"about_ca_system_score_gemma":0.001434995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006805456,"about_ca_topic_score_gemma":0.001283232,"domain_scores_codex":[0.9977853,0.001448742,0.0001513478,0.0002732129,0.0001752043,0.0001661242],"domain_scores_gemma":[0.9973465,0.0007599979,0.0008436456,0.0002686961,0.0001651642,0.0006159877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98252,0.006476732,0.000414267,0.0002983555,0.0005012567,0.00001696469,0.00003978258,0.0002233951,0.002041231,0.00004539775,0.0002806449,0.00714196],"study_design_scores_gemma":[0.895689,0.1021615,0.001111059,0.00001717769,0.0002015725,0.00002309351,0.00001026758,0.0002624386,0.0002457165,0.00005863525,0.0002087219,0.00001081755],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897494,0.004198621,0.0008395404,0.0005896674,0.0003567573,0.002382037,0.0006847445,0.0001273549,0.001071867],"genre_scores_gemma":[0.9897014,0.001463332,0.001661301,0.001052888,0.0006397183,0.003189581,0.0008437528,0.00003029966,0.001417718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005349128,"threshold_uncertainty_score":0.02496266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02016763466357224,"score_gpt":0.302727449078991,"score_spread":0.2825598144154188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}