{"id":"W4401696677","doi":"10.1186/s13046-024-03157-x","title":"SelK promotes glioblastoma cell proliferation by inhibiting β-TrCP1 mediated ubiquitin-dependent degradation of CDK4","year":2024,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University; Wenzhou Medical University","keywords":"Downregulation and upregulation; Ubiquitin; Cancer research; Cell growth; Viability assay; Cell cycle; Biology; Apoptosis; SKP2; Glioma; Ubiquitin ligase; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007924376,0.0003170079,0.0002389804,0.0002120074,0.000138564,0.0002244517,0.0001061653,0.00009419322,0.001125361],"category_scores_gemma":[0.00008801575,0.00007287983,0.0002577183,0.0001276013,0.0001766885,0.0001197709,0.000141702,0.0003192371,0.0003031294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002274544,"about_ca_system_score_gemma":0.0002215017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092825,"about_ca_topic_score_gemma":0.0006727598,"domain_scores_codex":[0.9999567,0.000005160357,0.000005027481,0.000007377954,0.000009150011,0.00001657395],"domain_scores_gemma":[0.9999551,0.000005111579,0.00001508578,0.000003543998,0.000005556653,0.00001556682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000907582,0.000193361,0.001666763,0.0001930036,0.0000369145,0.00008879117,0.0000195707,0.0001944559,0.9907045,0.00007214809,0.0002763542,0.005646443],"study_design_scores_gemma":[0.0001043756,0.0009546276,0.02758072,0.00001914959,0.00006286849,0.0003631073,0.00005696711,0.001656882,0.9663118,0.00008429887,0.002795469,0.000009739708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996415,0.001709338,0.000697172,0.00009014503,0.00002382431,0.00001524674,0.000296968,0.0000690274,0.0006832319],"genre_scores_gemma":[0.9969612,0.001155145,0.0005963749,0.00003130579,0.000007873523,0.00001776252,0.0004391842,0.00001032728,0.0007809211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125361,"threshold_uncertainty_score":0.003764749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07096634314589849,"score_gpt":0.4372020297358001,"score_spread":0.3662356865899016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}