{"id":"W4401698483","doi":"10.1038/s41698-024-00669-9","title":"A synthetic cytotoxic T cell platform for rapidly prototyping TCR function","year":2024,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Cancer Institute; Genome British Columbia; National Institutes of Health; Michael Smith Health Research BC; U.S. Department of Health and Human Services","keywords":"T-cell receptor; Cytotoxic T cell; Major histocompatibility complex; Biology; Antigen; Granzyme; Cell biology; T cell; Granzyme B; Computational biology; Immunology; Immune system; In vitro; Genetics; Perforin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002785898,0.0004004028,0.0001775532,0.0001828995,0.0001212458,0.0003679188,0.0004675368,0.0003709999,0.001335687],"category_scores_gemma":[0.0002912509,0.000166436,0.0002028591,0.0001225924,0.0002137628,0.0002831146,0.0003531039,0.0004618558,0.0004792152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199099,"about_ca_system_score_gemma":0.0002044375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001433553,"about_ca_topic_score_gemma":0.0001818145,"domain_scores_codex":[0.9997494,0.00004301697,0.00001810632,0.00004814787,0.00009916918,0.00004220925],"domain_scores_gemma":[0.9998471,0.0000285533,0.00004313921,0.00002612852,0.00002355473,0.00003150409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002585273,0.00001298931,0.00004476354,0.00003573356,0.000001742273,0.00006344574,0.00001321012,0.0006361487,0.9964935,0.0002682855,0.00004318058,0.002361012],"study_design_scores_gemma":[0.00001055985,0.0003059856,0.000158563,0.000004283403,0.000004941143,0.0002887536,0.000008822083,0.002346183,0.9935008,0.00008827348,0.003275022,0.000007824412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7983921,0.00110279,0.193161,0.0001709196,0.0001290687,0.0003025472,0.0005143558,0.0008805434,0.005346759],"genre_scores_gemma":[0.8757769,0.0009185675,0.117648,0.00008988284,0.00002186214,0.0002338462,0.0004710256,0.00009235449,0.004747494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335687,"threshold_uncertainty_score":0.004468322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05179868637115881,"score_gpt":0.3708730042852314,"score_spread":0.3190743179140726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}