{"id":"W4401698483","doi":"10.1038/s41698-024-00669-9","title":"A synthetic cytotoxic T cell platform for rapidly prototyping TCR function","year":2024,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Cancer Institute; Genome British Columbia; National Institutes of Health; Michael Smith Health Research BC; U.S. Department of Health and Human Services","keywords":"T-cell receptor; Cytotoxic T cell; Major histocompatibility complex; Biology; Antigen; Granzyme; Cell biology; T cell; Granzyme B; Computational biology; Immunology; Immune system; In vitro; Genetics; Perforin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001290773,0.000200995,0.0004384203,0.0004336252,0.0001193267,0.00005654335,0.0001491445,0.0003844794,0.0060799],"category_scores_gemma":[0.0002831033,0.0001615994,0.0002607906,0.0003689894,0.00008825163,0.0001251017,0.00008167698,0.0005177236,0.0005828033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006125193,"about_ca_system_score_gemma":0.0006149008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008599761,"about_ca_topic_score_gemma":0.00001104874,"domain_scores_codex":[0.998,0.00008753141,0.000426229,0.0005974945,0.0003952529,0.0004934964],"domain_scores_gemma":[0.9977764,0.001368208,0.00005739843,0.0004356339,0.0001670803,0.0001952351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004156316,0.0002174454,0.00002358239,0.000356802,0.00006622498,0.00005418682,0.0002997765,0.00000677226,0.357001,0.000300928,0.006898197,0.6306188],"study_design_scores_gemma":[0.002591304,0.006446848,0.0001552566,0.0002879516,0.0001136946,0.0002238446,0.0001376491,0.007667308,0.05712342,0.002687864,0.922394,0.0001708595],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7093907,0.008329466,0.07235608,0.006572591,0.006459272,0.02706364,0.00006024482,0.001376119,0.1683919],"genre_scores_gemma":[0.935978,0.0005735449,0.005020017,0.000760625,0.001361553,0.003313624,0.00006386144,0.0001665631,0.05276222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9154958,"threshold_uncertainty_score":0.9948287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05179868637115881,"score_gpt":0.3708730042852314,"score_spread":0.3190743179140726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}