{"id":"W4401700582","doi":"10.1080/15265161.2024.2361895","title":"When Gene Editing Should Be Mandatory","year":2024,"lang":"en","type":"letter","venue":"The American Journal of Bioethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto; Western University","funders":"","keywords":"Genome editing; Gene; Computer science; Biology; Genetics; CRISPR","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0103149,0.0004202288,0.0008436221,0.0004339329,0.003909812,0.00355164,0.00185505,0.06637605,0.008227907],"category_scores_gemma":[0.03157077,0.0005657918,0.001035725,0.000345905,0.006265023,0.006012098,0.002693238,0.0459846,0.004159241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003220877,"about_ca_system_score_gemma":0.006123344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004387166,"about_ca_topic_score_gemma":0.009518722,"domain_scores_codex":[0.9917499,0.001508337,0.0008083137,0.001357835,0.002859447,0.001716099],"domain_scores_gemma":[0.9816774,0.01247235,0.0007603606,0.000990955,0.001902435,0.002196527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00007380322,0.00006272492,0.0007705503,0.0001056989,0.00001937317,0.003996915,0.0007258158,0.00008259296,0.001524701,0.09333791,0.8750187,0.02428134],"study_design_scores_gemma":[0.00005925749,0.00007234793,0.0009552068,0.0003086985,0.00001664023,0.003093201,0.0007138224,0.0001566591,0.00102082,0.0680401,0.9255049,0.00005837107],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001104351,0.002042833,0.0006148761,0.9740118,0.009465083,0.00001325877,0.00003260079,0.00006086519,0.0126543],"genre_scores_gemma":[0.008655295,0.0006037531,0.0003988751,0.9771418,0.004930223,0.00002143615,0.00001745038,0.00003104202,0.008200184],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06637605,"threshold_uncertainty_score":0.05455106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03892618098825577,"score_gpt":0.3516482048839171,"score_spread":0.3127220238956613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}