{"id":"W4401701377","doi":"10.1128/jvi.00535-24","title":"A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets","year":2024,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Zhejiang Sci-Tech University; Government of Jiangsu Province; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Biology; Immune system; Virology; Messenger RNA; Coronavirus; Antibody; Immunization; Vaccination; Immunology; DNA vaccination; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Gene; Medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181696,0.0003542355,0.0001989142,0.0001646341,0.00007892928,0.0001536238,0.0001727505,0.0004291119,0.0004382597],"category_scores_gemma":[0.0001484239,0.0001006964,0.0002568911,0.00007588688,0.0001887116,0.0001825756,0.000158849,0.0003678032,0.0001373316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245495,"about_ca_system_score_gemma":0.000186562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000365319,"about_ca_topic_score_gemma":0.0004534098,"domain_scores_codex":[0.999885,0.00001289059,0.00001011767,0.00003239146,0.0000319437,0.00002765491],"domain_scores_gemma":[0.9999386,0.00001043182,0.00002103231,0.000005184701,0.00001252779,0.0000123006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005588261,0.00004704033,0.0001435475,0.00003903498,0.000004034541,0.00002919472,0.000006999574,0.0001246241,0.9969835,0.00003256789,0.00002703498,0.002506584],"study_design_scores_gemma":[0.00007299393,0.004072119,0.003722834,0.00001351418,0.00004207802,0.0002022281,0.0000232275,0.001689078,0.9878765,0.0000478847,0.002230479,0.000007076316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946564,0.0005875183,0.003744674,0.00007844373,0.00005832418,0.00005170681,0.0001015515,0.00004982859,0.0006714836],"genre_scores_gemma":[0.9929907,0.0006113814,0.004348175,0.0001483607,0.00001834789,0.00005476059,0.0004318773,0.00001536488,0.001380999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004382597,"threshold_uncertainty_score":0.001629174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03555341928238616,"score_gpt":0.251501472207192,"score_spread":0.2159480529248058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}