{"id":"W4401705615","doi":"10.1182/blood.2023023644","title":"Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Cancer research; Epigenetics; Myeloid leukemia; Biology; Chromatin; Leukemia; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009534233,0.0001623233,0.0001827438,0.0001302465,0.0001108027,0.0002530027,0.0001086577,0.0001064847,0.001737437],"category_scores_gemma":[0.00009772872,0.00007796109,0.0001143658,0.0001002453,0.0001464726,0.0001223958,0.0001756888,0.0003165471,0.0002945325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891493,"about_ca_system_score_gemma":0.0001295095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003117096,"about_ca_topic_score_gemma":0.0006576969,"domain_scores_codex":[0.9998927,0.00001231011,0.000009822276,0.00003186478,0.00002801497,0.00002534011],"domain_scores_gemma":[0.9999297,0.000007410128,0.00002906385,0.000006954416,0.000007977696,0.00001885086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161406,0.00001405891,0.000871868,0.00001955043,0.000003887724,0.00002260746,0.00001014272,0.00004055423,0.9974406,0.00004474165,0.00004036697,0.001375478],"study_design_scores_gemma":[0.00002066724,0.0002771713,0.05228122,0.000004692426,0.00002135846,0.0002344866,0.00003646408,0.0008687235,0.9435506,0.00004595814,0.002654099,0.000004562326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959022,0.001154467,0.001350775,0.00007169178,0.00001790781,0.00002118009,0.0004634973,0.00008861715,0.0009295793],"genre_scores_gemma":[0.9977132,0.0002895882,0.0003798403,0.00003142882,0.000005297704,0.00001221824,0.0002556117,0.000009436968,0.001303258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737437,"threshold_uncertainty_score":0.005812347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232853415937304,"score_gpt":0.2848471449487138,"score_spread":0.2725186107893408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}