{"id":"W4401705615","doi":"10.1182/blood.2023023644","title":"Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Cancer research; Epigenetics; Myeloid leukemia; Biology; Chromatin; Leukemia; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001147937,0.0002394308,0.0005082361,0.0005650892,0.00003875363,0.00003079248,0.0001815083,0.0002728481,0.0001955676],"category_scores_gemma":[0.0003598624,0.0002137877,0.0001448644,0.000925416,0.0001611236,0.0001242021,0.0001449461,0.0005490269,0.0001119249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007662307,"about_ca_system_score_gemma":0.001735763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008820627,"about_ca_topic_score_gemma":0.00001661465,"domain_scores_codex":[0.9974304,0.0002767337,0.0006370113,0.0005361418,0.0006244621,0.0004952111],"domain_scores_gemma":[0.9987008,0.0004196468,0.00006807932,0.0004930926,0.0001155785,0.0002027779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002548643,0.0002058651,0.001415043,0.0001880075,0.0002619674,0.000650154,0.0006661136,0.0001113383,0.9902457,0.0001453563,0.001189862,0.00237194],"study_design_scores_gemma":[0.005613573,0.001248646,0.07889874,0.0007997782,0.0003380881,0.0002898848,0.0000663981,0.009718333,0.9000218,0.0003796239,0.002345191,0.000279942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934673,0.003677252,0.0001330088,0.001202244,0.0001279383,0.0006352289,0.00003262759,0.0001089655,0.0006154702],"genre_scores_gemma":[0.9932848,0.0002815978,0.003375807,0.00005299842,0.0002183004,0.0000663898,0.00005734208,0.00006921237,0.002593565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0902239,"threshold_uncertainty_score":0.8718009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232853415937304,"score_gpt":0.2848471449487138,"score_spread":0.2725186107893408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}