{"id":"W4401710996","doi":"10.1016/j.celrep.2024.114590","title":"Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Mental Health; Office of Naval Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neuroscience; Optogenetics; Hippocampal formation; Entorhinal cortex; GABAergic; Hippocampus; Grid cell; Biology; Spatial memory; Population; Inhibitory postsynaptic potential; Grid; Working memory; Medicine; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005146159,0.0002228746,0.0002492631,0.0001271877,0.0001178994,0.00008261089,0.0001982156,0.00008314945,0.0001285854],"category_scores_gemma":[0.0002223034,0.0001662105,0.0001239872,0.0002744098,0.0001864092,0.0001506539,0.0001256609,0.0003573144,0.000007727474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002048592,"about_ca_system_score_gemma":0.0001140443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003654083,"about_ca_topic_score_gemma":0.00003945719,"domain_scores_codex":[0.9975906,0.0002294438,0.0005829431,0.0006542852,0.0005859543,0.0003567765],"domain_scores_gemma":[0.9989054,0.0004408271,0.0002023704,0.0003079062,0.00001375436,0.000129793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002702557,0.00005901611,0.000817309,0.0001387989,9.466915e-7,0.007031424,0.001692258,0.00001428096,0.9897637,0.00002982658,0.0001055657,0.0003198661],"study_design_scores_gemma":[0.0001946917,0.0002401098,0.001219875,0.00006912462,0.00003465185,0.001139417,0.0001715138,0.001195694,0.9951237,0.0002681332,0.000164664,0.0001783721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934451,0.0002690368,0.00006312233,0.00006824298,0.003969608,0.0003758526,0.00001266565,0.00004639137,0.001749987],"genre_scores_gemma":[0.9991094,0.00007952125,0.00002693867,0.0001059537,0.0004554818,0.0000181404,0.000006387953,0.00002516393,0.0001730342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005892007,"threshold_uncertainty_score":0.6777869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03796429569463448,"score_gpt":0.2827845150659822,"score_spread":0.2448202193713477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}