{"id":"W4401710996","doi":"10.1016/j.celrep.2024.114590","title":"Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Mental Health; Office of Naval Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neuroscience; Optogenetics; Hippocampal formation; Entorhinal cortex; GABAergic; Hippocampus; Grid cell; Biology; Spatial memory; Population; Inhibitory postsynaptic potential; Grid; Working memory; Medicine; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037124,0.0003260846,0.0002016526,0.0002222453,0.000113152,0.0002647664,0.0003271287,0.000288833,0.0007626241],"category_scores_gemma":[0.0001291501,0.0001923859,0.0002301896,0.0001035685,0.0004756412,0.0001930881,0.0002344448,0.0007234993,0.000239028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815913,"about_ca_system_score_gemma":0.0003250864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264198,"about_ca_topic_score_gemma":0.002472255,"domain_scores_codex":[0.9998704,0.00001138465,0.00001853448,0.00002907791,0.00003239627,0.00003825676],"domain_scores_gemma":[0.9998152,0.00002261827,0.00007765921,0.00001888141,0.00001025634,0.00005544493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008376838,0.00001338663,0.000107696,0.00001304547,0.00000393969,0.00003303429,0.000007555983,0.00009684848,0.9989612,0.0001173364,0.00001597859,0.000546259],"study_design_scores_gemma":[0.00003344179,0.0001742629,0.006561344,0.000008026458,0.0000221919,0.0001295909,0.00006184173,0.002072523,0.9902064,0.0001434647,0.0005809844,0.000005865511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963781,0.000220066,0.00228676,0.00007870723,0.00003309411,0.000009175566,0.0002401331,0.00006512227,0.0006888061],"genre_scores_gemma":[0.9966092,0.0002137117,0.001645243,0.0000406511,0.000004622071,0.00002010156,0.0001138915,0.00003445538,0.001318144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264198,"threshold_uncertainty_score":0.002551198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03796429569463448,"score_gpt":0.2827845150659822,"score_spread":0.2448202193713477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}