{"id":"W4401713876","doi":"10.1021/acsptsci.4c00462","title":"Colon-Targeted Sustained-Release Combinatorial 5-Fluorouracil and Quercetin poly(lactic-<i>co</i>-glycolic) Acid (PLGA) Nanoparticles Show Enhanced Apoptosis and Minimal Tumor Drug Resistance for Their Potential Use in Colon Cancer","year":2024,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Ministry of Higher Education; Government of Canada","keywords":"PLGA; Glycolic acid; Apoptosis; Lactic acid; Fluorouracil; Pharmacology; Chemistry; Colorectal cancer; Drug; Cancer research; Medicine; In vitro; Chemotherapy; Biochemistry; Cancer; Internal medicine; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006111775,0.0002218045,0.0001220222,0.0001394595,0.00006325845,0.0001240852,0.0001219572,0.0002296961,0.0004723665],"category_scores_gemma":[0.00006825818,0.0001128849,0.0001457545,0.00008938488,0.0001126924,0.0001502027,0.00008464323,0.0001879445,0.0001113337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002207423,"about_ca_system_score_gemma":0.0001078032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008260061,"about_ca_topic_score_gemma":0.001498286,"domain_scores_codex":[0.9999495,0.000005496229,0.000003103445,0.00001632902,0.00001536877,0.00001020486],"domain_scores_gemma":[0.9999732,0.000003660216,0.000009938251,0.000002074899,0.000005600902,0.000005546493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003902313,0.00001143918,0.00004161334,0.00001215952,0.000002163364,0.00001381586,0.000002968558,0.0001310677,0.9985666,0.00003246493,0.0000231954,0.00112362],"study_design_scores_gemma":[0.00001324573,0.0002779016,0.001042238,0.000001725951,0.0000140813,0.00008324112,0.000004495173,0.002384964,0.9953107,0.00001378066,0.0008486551,0.000004879027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904355,0.001084852,0.007181367,0.00004891222,0.00001919307,0.00002949631,0.00009785948,0.00009867499,0.001004218],"genre_scores_gemma":[0.993138,0.0003738838,0.0048235,0.00002675751,0.000003727843,0.00002526819,0.0001003146,0.00001135864,0.001497301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008260061,"threshold_uncertainty_score":0.001642406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195498026577738,"score_gpt":0.2805190869191501,"score_spread":0.2685641066533727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}