{"id":"W4401714784","doi":"10.1128/spectrum.01047-24","title":"Exploring antimicrobial interactions between metal ions and quaternary ammonium compounds toward synergistic metallo-antimicrobial formulations","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antimicrobial; Ammonium; Bromide; Biofilm; Chemistry; Benzalkonium chloride; Ammonium bromide; Antibiotics; Metal; Metal ions in aqueous solution; Antibiotic resistance; Ammonium chloride; Combinatorial chemistry; Microbiology; Chromatography; Bacteria; Biology; Biochemistry; Organic chemistry; Pulmonary surfactant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001441112,0.0003415315,0.0003757652,0.000191932,0.000340514,0.0001499318,0.000198157,0.0001434926,0.00004089598],"category_scores_gemma":[0.00001974655,0.0003038073,0.0002479052,0.0001537301,0.0003695675,0.00005604708,0.0002478652,0.0002558274,0.00004218549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003945961,"about_ca_system_score_gemma":0.00006571542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674358,"about_ca_topic_score_gemma":0.0001413964,"domain_scores_codex":[0.998417,0.00008324598,0.0003693211,0.0006051219,0.00004159793,0.0004836823],"domain_scores_gemma":[0.9994817,0.00007194965,0.00007007582,0.0002550104,0.00003031781,0.00009094363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004930807,0.00006237303,0.0009345508,0.00008107166,0.0004223864,0.00001246362,0.0001605581,0.00001421082,0.9953087,0.0006684778,0.001609307,0.0006765682],"study_design_scores_gemma":[0.0003753237,0.0002049249,0.00197092,0.0001326495,0.0003422343,0.000568234,0.0001104737,0.0000988354,0.917383,0.0003388827,0.07783784,0.0006367274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922774,0.0008089507,0.003222068,0.001279609,0.001131187,0.0001618237,0.0004395108,0.00009212786,0.0005872523],"genre_scores_gemma":[0.9962884,0.0004214247,0.0006236476,0.0001103991,0.001119776,0.00002697145,0.0006235827,0.00005272531,0.0007331035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07792577,"threshold_uncertainty_score":0.9999414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05443843693104219,"score_gpt":0.2656181921724223,"score_spread":0.2111797552413801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}