{"id":"W4401715124","doi":"10.1158/1078-0432.ccr-24-1023","title":"Novel <i>ERBB2</i> Variant Potentially Associated with Resistance against Anti-HER2 Monoclonal Antibody–Based Therapy in <i>ERBB2</i> -Amplified Metastatic Colorectal Cancer","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; National Cancer Center Japan; Institute of Genetics; Daiichi Sankyo Company; Japan Agency for Medical Research and Development; Clinical Trial Center, China Medical University Hospital","keywords":"Medicine; Colorectal cancer; Targeted therapy; Monoclonal antibody; Oncology; Internal medicine; Trastuzumab; Monoclonal; Cancer; Acquired resistance; Antibody; Immunology; Breast cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002782094,0.0002610808,0.0003170097,0.0004448294,0.0003207955,0.0003566031,0.0001878492,0.0003320483,0.000725999],"category_scores_gemma":[0.0006063637,0.0001252767,0.0003272743,0.0005518902,0.0003070356,0.000115018,0.000173126,0.000364853,0.0001216852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002324666,"about_ca_system_score_gemma":0.0001759555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248737,"about_ca_topic_score_gemma":0.001939476,"domain_scores_codex":[0.999772,0.00004275345,0.00002536009,0.00008206138,0.00003812669,0.00003966761],"domain_scores_gemma":[0.9994698,0.0001021101,0.0002778429,0.00003328194,0.00003367888,0.00008321593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00219934,0.0001749332,0.8912301,0.00004688683,0.0001749876,0.004400863,0.0002001933,0.0004669782,0.09504855,0.00008995898,0.0003002914,0.005666994],"study_design_scores_gemma":[0.00008029611,0.0005299356,0.9832759,0.000006247306,0.0001144824,0.006733358,0.0001327143,0.001173639,0.007486751,0.00006264241,0.0003912456,0.00001280784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997659,0.00002749461,0.00006001407,0.00001027411,0.000001080973,0.00000445371,0.0000753183,0.000002368151,0.00005300705],"genre_scores_gemma":[0.9995835,0.00001253727,0.0001441587,0.00002403261,0.000003776459,0.000004076524,0.0001866508,0.000002585278,0.00003860424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248737,"threshold_uncertainty_score":0.002482891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1574445498303027,"score_gpt":0.4806459276473874,"score_spread":0.3232013778170847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}