{"id":"W4401715291","doi":"10.1111/bjh.19706","title":"<scp>PembroWM</scp> : A phase <scp>II</scp> trial to investigate the safety and efficacy of rituximab and pembrolizumab in relapsed/refractory Waldenström's Macroglobulinaemia","year":2024,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Merck Sharp and Dohme","keywords":"Medicine; Rituximab; Internal medicine; Chemoimmunotherapy; Tolerability; Refractory (planetary science); Oncology; Pembrolizumab; Gastroenterology; Phases of clinical research; Clinical trial; Adverse effect; Immunotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001397869,0.0007961941,0.0009146429,0.0003191385,0.0003208178,0.0006647485,0.0004732661,0.0008619205,0.004814199],"category_scores_gemma":[0.0005800953,0.0002497316,0.0006821479,0.0002849379,0.0004667962,0.0004540722,0.0004884227,0.00166931,0.0008031945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006401784,"about_ca_system_score_gemma":0.001452083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113795,"about_ca_topic_score_gemma":0.003385512,"domain_scores_codex":[0.9996616,0.0001939669,0.00001420394,0.00003934522,0.00003712179,0.00005372221],"domain_scores_gemma":[0.9995465,0.00006082395,0.00008004357,0.00002396165,0.00002728613,0.0002613463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7507625,0.01977996,0.008904937,0.001901305,0.001671211,0.0005779089,0.0002925963,0.002436447,0.06370772,0.0008861362,0.01521676,0.1338625],"study_design_scores_gemma":[0.8080934,0.157424,0.01882318,0.000123177,0.0004931229,0.0005200673,0.00005631832,0.001152855,0.004203416,0.0003757906,0.008707205,0.00002752371],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828631,0.003323038,0.0005547594,0.0011477,0.000112301,0.004673951,0.002680929,0.0001223361,0.004521909],"genre_scores_gemma":[0.9798419,0.001839122,0.002274354,0.001489763,0.000160984,0.004447716,0.005494897,0.00003916167,0.004412109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004814199,"threshold_uncertainty_score":0.01610512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723235397203564,"score_gpt":0.3111091422852666,"score_spread":0.2938767883132309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}