{"id":"W4401715865","doi":"10.1128/spectrum.00532-24","title":"PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in <i>Escherichia coli</i>","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Saskatchewan; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Beef Cattle Research Council; Government of Alberta; Alberta Beef Producers","keywords":"Colistin; MCR-1; Escherichia coli; Phylogenetics; Biology; Microbiology; Genetics; Escherichia coli Proteins; Enterobacteriaceae; Gene; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005955566,0.0002438019,0.0003465675,0.001019332,0.0003098962,0.0006084954,0.0001583853,0.0003703165,0.001317538],"category_scores_gemma":[0.001438972,0.0001656668,0.0004767928,0.001410223,0.0002827376,0.000154027,0.0003168484,0.0003749429,0.0003985393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072798,"about_ca_system_score_gemma":0.0002029543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001855054,"about_ca_topic_score_gemma":0.002910117,"domain_scores_codex":[0.9992751,0.000127328,0.0001102026,0.0002478097,0.0001311097,0.000108353],"domain_scores_gemma":[0.9984938,0.0003493191,0.0007010399,0.0001651277,0.0001715555,0.0001191163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001177235,0.0001331261,0.711282,0.000243936,0.0002563983,0.0007795118,0.0005105361,0.0005902836,0.2743338,0.0001611525,0.000814326,0.009717715],"study_design_scores_gemma":[0.00001124723,0.0001199022,0.9827685,0.00004488786,0.0001091357,0.00151897,0.0002856929,0.0008457413,0.01193494,0.00006307858,0.00228738,0.00001053719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962431,0.0002772831,0.0005456496,0.00003325806,0.000005516621,0.00001059421,0.002357414,0.00001293561,0.0005142743],"genre_scores_gemma":[0.9943894,0.00008523853,0.0008694039,0.00004220696,0.000004182276,0.00001031194,0.004419646,0.00001531606,0.0001644387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855054,"threshold_uncertainty_score":0.004407585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007331063235271695,"score_gpt":0.2110684385350322,"score_spread":0.2037373752997605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}