{"id":"W4401727995","doi":"10.1371/journal.pone.0309324","title":"KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; York University","keywords":"Leucine; Internal medicine; GLUT4; Endocrinology; Insulin; Skeletal muscle; Insulin receptor; Insulin resistance; P70-S6 Kinase 1; Metabolite; Glucose uptake; Protein kinase B; Amino acid; Chemistry; Biology; Phosphorylation; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002284742,0.0008377622,0.0008253641,0.001009359,0.0003549872,0.0003455611,0.0003692049,0.000441545,0.001544533],"category_scores_gemma":[0.0001824212,0.0005292993,0.0007515867,0.0003914784,0.0007268882,0.000634924,0.0003862642,0.001754633,0.0003717366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000447821,"about_ca_system_score_gemma":0.0006574945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001931461,"about_ca_topic_score_gemma":0.00274463,"domain_scores_codex":[0.999673,0.00002718314,0.00003591707,0.00008291278,0.00007293716,0.0001080912],"domain_scores_gemma":[0.99964,0.0000210371,0.00008273359,0.00003838025,0.00003090161,0.0001869845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0128449,0.001532632,0.001260153,0.0001004282,0.00005265711,0.000196168,0.00008636198,0.0001362958,0.9785518,0.0001442096,0.0001319645,0.00496245],"study_design_scores_gemma":[0.0009701046,0.03092388,0.0355574,0.000031712,0.0002291796,0.0005792024,0.0004251327,0.001107206,0.9263909,0.0002767832,0.003425864,0.00008268157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997552,0.0007565694,0.0005114554,0.000102496,0.00004683191,0.00003727365,0.0003682662,0.00005815273,0.0005669078],"genre_scores_gemma":[0.9890372,0.001720697,0.001957899,0.0001960676,0.00003260064,0.0002169273,0.0008872293,0.00004600668,0.005905405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001931461,"threshold_uncertainty_score":0.005167007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0340552194929643,"score_gpt":0.2656432951573273,"score_spread":0.231588075664363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}