{"id":"W4401728325","doi":"10.1097/cad.0000000000001658","title":"Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer","year":2024,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Tulane University; Pfizer; Bristol-Myers Squibb","keywords":"Kinome; Cyclin-dependent kinase 4; Triple-negative breast cancer; Cancer research; Kinase; Cyclin-dependent kinase; Cyclin-dependent kinase 7; Biology; Cyclin-dependent kinase 2; Cyclin-dependent kinase 9; Cancer; Cell biology; Cell cycle; Breast cancer; Protein kinase A; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751721,0.0005734594,0.0007935627,0.0009455952,0.0002480877,0.0004170408,0.0002925617,0.0002701758,0.002334986],"category_scores_gemma":[0.000189365,0.000200336,0.0003891362,0.0007946418,0.0001604763,0.0002172087,0.0002622203,0.0004423983,0.0006150728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003442206,"about_ca_system_score_gemma":0.0005077549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008167353,"about_ca_topic_score_gemma":0.002745884,"domain_scores_codex":[0.9998667,0.00001472203,0.0000109578,0.00003009671,0.00004997519,0.00002748126],"domain_scores_gemma":[0.9999366,0.00001613903,0.00001108755,0.000006266324,0.00001434182,0.00001558802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004285131,0.0004527997,0.001258937,0.000395068,0.0000780938,0.0005038344,0.00004063972,0.001738146,0.9663101,0.0002853879,0.000754934,0.02775355],"study_design_scores_gemma":[0.0003753947,0.006168179,0.01930348,0.0001229117,0.0005026125,0.00261499,0.0001197078,0.005272085,0.940885,0.0002784094,0.0243037,0.00005356605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686765,0.009409368,0.006463708,0.0003242876,0.00005945102,0.0006070253,0.006285877,0.0004188135,0.007754833],"genre_scores_gemma":[0.9616858,0.01155314,0.0093383,0.0002942766,0.00002274849,0.0002506649,0.01025664,0.00004603199,0.006552456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334986,"threshold_uncertainty_score":0.007811308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825964053707128,"score_gpt":0.2670174725904091,"score_spread":0.2487578320533378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}