{"id":"W4401728710","doi":"10.1097/pgp.0000000000001033","title":"Improved Risk Prediction in Human Papillomavirus–Associated Endocervical Adenocarcinoma Through Assessment of Binary Silva Pattern-based Classification: An International Multicenter Retrospective Observational Study Led by the International Society of Gynecological Pathologists (ISGyP)","year":2024,"lang":"en","type":"article","venue":"International Journal of Gynecological Pathology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of Toronto; University Health Network","funders":"Dell Medical School, University of Texas at Austin; School of Medicine, Indiana University; University of Colorado School of Medicine, Anschutz Medical Campus; University of British Columbia; Jilin University; University of Hong Kong; General Hospital of People’s Liberation Army; Ministero della Salute; University of Notre Dame Australia; Australian National University; University of Alabama; Fourth Military Medical University; Queen Mary University of London; Leonard M. Miller School of Medicine; University of California, San Diego; University of Toronto; Yale University; Dartmouth College; Univerzita Karlova v Praze; Postgraduate Institute of Medical Education and Research, Chandigarh; Medical Center, University of Rochester; Massachusetts General Hospital; Case Western Reserve University; Brigham and Women's Hospital; Emory University; Cleveland Clinic; NYU Langone Medical Center; Všeobecná Fakultní Nemocnice v Praze; York University; University of Miami; Memorial Sloan-Kettering Cancer Center; University of Alabama at Birmingham; Guangzhou Medical University; University of Notre Dame; Brown University","keywords":"Medicine; Stage (stratigraphy); Retrospective cohort study; Oncology; Internal medicine; Gynecology; Lymphovascular invasion; Not Otherwise Specified; Adenocarcinoma; Pathology; Cancer; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001860497,0.0003516164,0.0008635363,0.0003079003,0.00009646062,0.00006785116,0.00101601,0.0004031472,0.001295924],"category_scores_gemma":[0.001495732,0.0002324616,0.0006014908,0.0004337433,0.0004584843,0.0004153955,0.0002437045,0.001183649,0.000003267386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001638966,"about_ca_system_score_gemma":0.0003454756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001292308,"about_ca_topic_score_gemma":0.00006780862,"domain_scores_codex":[0.9948934,0.000705255,0.002033389,0.0006514982,0.001397168,0.0003192677],"domain_scores_gemma":[0.9952603,0.001557397,0.001323899,0.0002862794,0.001447943,0.0001241982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001003478,0.008291968,0.9576041,0.00001956199,0.001185267,0.0006098749,0.000449888,0.0001848173,0.02775886,0.000203528,0.0004383865,0.002250336],"study_design_scores_gemma":[0.009276286,0.006364453,0.9652556,0.00009367069,0.0002676328,0.0001002562,0.0006609529,0.01634925,0.0006425356,0.0006737222,0.0001530663,0.0001625606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903093,0.0002015463,0.001252867,0.003799251,0.002415345,0.0008057588,0.0007085174,0.00004617235,0.0004612648],"genre_scores_gemma":[0.9965326,0.0001917062,0.001272177,0.0008323528,0.0004408189,0.0001239592,0.0005212696,0.00002525251,0.00005984683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02711633,"threshold_uncertainty_score":0.999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08258690734433227,"score_gpt":0.3916554043537601,"score_spread":0.3090684970094278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}