{"id":"W4401728710","doi":"10.1097/pgp.0000000000001033","title":"Improved Risk Prediction in Human Papillomavirus–Associated Endocervical Adenocarcinoma Through Assessment of Binary Silva Pattern-based Classification: An International Multicenter Retrospective Observational Study Led by the International Society of Gynecological Pathologists (ISGyP)","year":2024,"lang":"en","type":"article","venue":"International Journal of Gynecological Pathology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of Toronto; University Health Network","funders":"Dell Medical School, University of Texas at Austin; School of Medicine, Indiana University; University of Colorado School of Medicine, Anschutz Medical Campus; University of British Columbia; Jilin University; University of Hong Kong; General Hospital of People’s Liberation Army; Ministero della Salute; University of Notre Dame Australia; Australian National University; University of Alabama; Fourth Military Medical University; Queen Mary University of London; Leonard M. Miller School of Medicine; University of California, San Diego; University of Toronto; Yale University; Dartmouth College; Univerzita Karlova v Praze; Postgraduate Institute of Medical Education and Research, Chandigarh; Medical Center, University of Rochester; Massachusetts General Hospital; Case Western Reserve University; Brigham and Women's Hospital; Emory University; Cleveland Clinic; NYU Langone Medical Center; Všeobecná Fakultní Nemocnice v Praze; York University; University of Miami; Memorial Sloan-Kettering Cancer Center; University of Alabama at Birmingham; Guangzhou Medical University; University of Notre Dame; Brown University","keywords":"Medicine; Stage (stratigraphy); Retrospective cohort study; Oncology; Internal medicine; Gynecology; Lymphovascular invasion; Not Otherwise Specified; Adenocarcinoma; Pathology; Cancer; Metastasis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001600034,0.0003755497,0.000347265,0.0006451731,0.0003528856,0.0008014471,0.0004546283,0.0004657331,0.0004906231],"category_scores_gemma":[0.003380986,0.0003614736,0.0005938587,0.00089761,0.0003088553,0.0005983929,0.0006365855,0.0005997773,0.000167898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433537,"about_ca_system_score_gemma":0.0003411566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002519994,"about_ca_topic_score_gemma":0.002678627,"domain_scores_codex":[0.9992919,0.0002560129,0.00007076004,0.0001876587,0.000118743,0.00007493591],"domain_scores_gemma":[0.9983759,0.0002502633,0.0006998529,0.0002817124,0.0001913947,0.0002009379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009361482,0.00001911748,0.9992837,0.000002304824,0.00002461644,0.00001885867,0.0000279733,0.00001948015,0.00009857294,0.000005700024,0.00002341864,0.0003825129],"study_design_scores_gemma":[0.00001251305,0.0001310863,0.998755,0.000003394142,0.00003776877,0.0001839914,0.00013966,0.0005462656,0.00005760088,0.00002049262,0.0001078477,0.000004369289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994704,0.00007879618,0.000153002,0.00001123812,0.000003457021,0.000008170264,0.0001599086,0.000001648627,0.000113391],"genre_scores_gemma":[0.9994375,0.00004789662,0.000140397,0.00001138399,0.000006788866,0.000008953546,0.0003123863,0.000001839111,0.00003288849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002519994,"threshold_uncertainty_score":0.008461833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08258690734433227,"score_gpt":0.3916554043537601,"score_spread":0.3090684970094278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}