{"id":"W4401744308","doi":"10.1002/hem3.116","title":"RNA binding protein‐directed control of leukemic stem cell evolution and function","year":2024,"lang":"en","type":"review","venue":"HemaSphere","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Haematopoiesis; Stem cell; Biology; Myeloid leukemia; RNA-binding protein; Myeloid; Hematopoietic stem cell; Leukemia; Function (biology); Disease; Transcriptome; RNA; Computational biology; Cancer research; Immunology; Gene; Gene expression; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000348303,0.0002021395,0.0001321091,0.0001255437,0.0001880438,0.000565145,0.0002431644,0.0002928109,0.001241997],"category_scores_gemma":[0.0002241954,0.00009331539,0.00009948516,0.0001133409,0.0004966957,0.0002849341,0.0002555762,0.0004589919,0.0007013571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004818325,"about_ca_system_score_gemma":0.0002399075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00025969,"about_ca_topic_score_gemma":0.0004872276,"domain_scores_codex":[0.9998254,0.00003088919,0.000008400456,0.00005968367,0.00005355345,0.00002213179],"domain_scores_gemma":[0.9999251,0.0000190317,0.00002230253,0.00001172426,0.000008439035,0.00001335375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003746686,0.000006526299,0.0001401137,0.00004063624,0.000002046656,0.00004086997,0.00003444585,0.0003165655,0.9785798,0.008815309,0.0003134642,0.01167285],"study_design_scores_gemma":[0.000009985145,0.000090738,0.002039342,0.00001558249,0.000006884689,0.0002706225,0.00005283159,0.003887716,0.9456854,0.003708574,0.04421994,0.00001232951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7677376,0.04830521,0.1324921,0.002732286,0.0005742854,0.00008317212,0.0008942242,0.001720657,0.04546048],"genre_scores_gemma":[0.9719279,0.00818238,0.0112873,0.0003305486,0.00007006531,0.00002645106,0.0002416966,0.0001256109,0.007807921],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001241997,"threshold_uncertainty_score":0.004154921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744990871103646,"score_gpt":0.2712963733619915,"score_spread":0.2538464646509551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}