{"id":"W4401744308","doi":"10.1002/hem3.116","title":"RNA binding protein‐directed control of leukemic stem cell evolution and function","year":2024,"lang":"en","type":"review","venue":"HemaSphere","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Haematopoiesis; Stem cell; Biology; Myeloid leukemia; RNA-binding protein; Myeloid; Hematopoietic stem cell; Leukemia; Function (biology); Disease; Transcriptome; RNA; Computational biology; Cancer research; Immunology; Gene; Gene expression; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878145,0.0002524111,0.0005664072,0.00006427485,0.00004930587,0.0000271519,0.0001083,0.0003618016,0.00001816393],"category_scores_gemma":[0.00001770747,0.0001988026,0.0002174752,0.000169851,0.00004525206,0.000003295489,0.00008067281,0.0002475571,0.00003094707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007245193,"about_ca_system_score_gemma":0.0003119418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002170087,"about_ca_topic_score_gemma":0.000008508562,"domain_scores_codex":[0.9987464,0.0001167892,0.0003293771,0.0004086104,0.0001530639,0.0002457697],"domain_scores_gemma":[0.9994104,0.00001357366,0.000169308,0.0002584486,0.00006381804,0.00008447722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006625237,0.00002981726,0.00000618571,0.03570233,0.0003242165,0.00000955625,0.000005496006,0.000001130899,0.445367,0.0000818452,0.001782835,0.5166233],"study_design_scores_gemma":[0.0008955655,0.000732756,0.000002676075,0.01334364,0.001121901,0.00005219145,0.00008820567,0.0001827787,0.01415163,0.00002433696,0.9687836,0.0006207144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01234902,0.9855736,0.0005329048,0.000003136456,0.00009084556,0.0007835053,0.00004844118,0.00002742301,0.0005911301],"genre_scores_gemma":[0.0143626,0.9671285,0.0000526557,0.000002700147,0.0001753034,0.0001234636,0.0001093745,0.00005673859,0.01798869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9670008,"threshold_uncertainty_score":0.8106933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744990871103646,"score_gpt":0.2712963733619915,"score_spread":0.2538464646509551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}