{"id":"W4401745029","doi":"10.1002/hem3.130","title":"Biomarkers of outcome in patients undergoing CD19 CAR‐T therapy for large B cell lymphoma","year":2024,"lang":"en","type":"review","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"University of Toronto","keywords":"Chimeric antigen receptor; Chemoimmunotherapy; Medicine; Oncology; Refractory (planetary science); Lymphoma; Internal medicine; CD19; Disease; Immunotherapy; Antigen; Immunology; Rituximab; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005888019,0.0005626128,0.002399746,0.0003354845,0.00003591604,0.00002783687,0.0002897116,0.0005236659,0.001291447],"category_scores_gemma":[0.00009673792,0.0004195338,0.001205706,0.00077009,0.00004950426,0.00004233799,0.0001230928,0.0003382926,0.0001061176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006318236,"about_ca_system_score_gemma":0.0008078872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004985653,"about_ca_topic_score_gemma":0.0000676795,"domain_scores_codex":[0.9968094,0.0001430995,0.001126053,0.000670303,0.0005841402,0.0006670092],"domain_scores_gemma":[0.9982049,0.0004710866,0.0002800871,0.000746145,0.0001348308,0.0001629483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003987946,0.001322899,0.003289922,0.1296095,0.0008833665,0.00005689137,0.0001579052,5.946432e-8,0.00001747848,0.0000837355,0.004792445,0.859387],"study_design_scores_gemma":[0.009081463,0.0006797176,0.0000945026,0.01381661,0.0005371784,0.000008410572,0.00009937505,0.000008314863,0.00004747513,0.00003434288,0.9752249,0.000367748],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001678542,0.9890791,0.000009661248,0.00002444433,0.0004133862,0.00404625,0.0001991101,0.00005509227,0.004494371],"genre_scores_gemma":[0.0006320687,0.983705,0.0002170092,0.00005617644,0.0001439966,0.0003296125,0.0003515407,0.0002614646,0.01430317],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9704324,"threshold_uncertainty_score":0.9998257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06631002535945682,"score_gpt":0.379980524641565,"score_spread":0.3136704992821082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}