{"id":"W4401750382","doi":"10.2139/ssrn.4931207","title":"Safety and Immunogenicity of Covac-2, a Sepivac Swe™ Adjuvanted Sars-Cov-2 Recombinant Protein Vaccine in Healthy Adults; a Randomized Controlled First-in-Human Dose-Escalation Trial","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"","keywords":"Immunogenicity; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Virology; Recombinant DNA; 2019-20 coronavirus outbreak; Immunology; Antibody; Biology; Internal medicine; Outbreak; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001896594,0.001909426,0.002405623,0.000288164,0.000362517,0.001160668,0.0005971729,0.00222697,0.003647172],"category_scores_gemma":[0.001722224,0.0006919915,0.001617548,0.0002872761,0.00120102,0.001277586,0.0003190162,0.002683948,0.0008978205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000678557,"about_ca_system_score_gemma":0.0008533274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005165925,"about_ca_topic_score_gemma":0.0004906359,"domain_scores_codex":[0.9991485,0.0004127068,0.00004879734,0.0001760866,0.00007038292,0.0001434236],"domain_scores_gemma":[0.9992464,0.0001813004,0.0001874064,0.00008855296,0.0000664074,0.0002301274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9767476,0.006119498,0.001069326,0.0002286239,0.0007041779,0.00003212253,0.00004774139,0.0002566162,0.00344665,0.00006087837,0.0004368614,0.01084983],"study_design_scores_gemma":[0.7375942,0.2515677,0.006630125,0.00004253108,0.001001245,0.00005180539,0.00004080901,0.0006246077,0.001272623,0.0002453374,0.0008981935,0.00003093249],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949681,0.002154312,0.0003246062,0.0002280538,0.0001865887,0.0008453074,0.0004738406,0.00003413529,0.0007850802],"genre_scores_gemma":[0.9932782,0.001242129,0.0005672388,0.0006952312,0.00029649,0.001181793,0.0007951727,0.00001839196,0.001925276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003647172,"threshold_uncertainty_score":0.01220101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757173827289489,"score_gpt":0.3350126838963816,"score_spread":0.3174409456234867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}