{"id":"W4401753302","doi":"10.1016/j.ijbiomac.2024.134960","title":"An investigation of functionalized chitosan and alginate multilayer conformal nanocoating on mouse beta cell spheroids as a model for pancreatic islet transplantation","year":2024,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; McGill University","keywords":"Spheroid; Islet; Transplantation; BETA (programming language); Beta cell; Chitosan; Cell; Chemistry; Pancreatic islets; Conformal map; Tissue engineering; Biomedical engineering; Cell biology; Internal medicine; Medicine; Biology; Insulin; Biochemistry; In vitro; Computer science; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319914,0.000279865,0.0002214339,0.0001493501,0.0001004752,0.0002750818,0.0001386278,0.0003004098,0.0003165495],"category_scores_gemma":[0.0001132639,0.0001040432,0.0003057888,0.0001553272,0.0001124156,0.000177364,0.000126608,0.0002726442,0.0001133723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192327,"about_ca_system_score_gemma":0.0001627583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145286,"about_ca_topic_score_gemma":0.001431595,"domain_scores_codex":[0.9999049,0.000009885245,0.000007505681,0.00002473923,0.00003531686,0.00001768036],"domain_scores_gemma":[0.9999027,0.00001934983,0.00002910887,0.00001119651,0.00001721771,0.00002045168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001404003,0.000007483252,0.00003668879,0.00001354787,0.000001591636,0.00002200743,0.000005760669,0.00004846108,0.999552,0.000008579771,0.000005383737,0.000284594],"study_design_scores_gemma":[0.0000041835,0.0002511663,0.001312493,0.00000322336,0.00001500384,0.000073624,0.00001187272,0.0008035053,0.9969958,0.00000660462,0.0005188095,0.000003789887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935206,0.001087708,0.004398855,0.00004003148,0.00004141925,0.00004617533,0.0001934987,0.00005577259,0.0006158601],"genre_scores_gemma":[0.9923551,0.001063535,0.005250113,0.00003670701,0.000008568167,0.00004131389,0.00017711,0.00002283942,0.001044702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145286,"threshold_uncertainty_score":0.002277255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02590685053630985,"score_gpt":0.2985752080354622,"score_spread":0.2726683574991524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}