{"id":"W4401764025","doi":"10.61186/nl.3.2.39","title":"Metformin attenuates white matter microstructural changes in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Neurology Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Metformin; White matter; White (mutation); Medicine; Internal medicine; Cardiology; Endocrinology; Chemistry; Diabetes mellitus; Magnetic resonance imaging; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174808,0.0001843402,0.0001871088,0.0002240014,0.0001279748,0.0002112489,0.0001056217,0.0001243851,0.0008300747],"category_scores_gemma":[0.0007127468,0.00006695802,0.0001547985,0.0001428549,0.00008607555,0.0001574022,0.0001537765,0.0002135379,0.00008658646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000100202,"about_ca_system_score_gemma":0.0001790766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007477525,"about_ca_topic_score_gemma":0.001488864,"domain_scores_codex":[0.9999515,0.00001579734,0.000004705969,0.000006881796,0.000009629409,0.00001157884],"domain_scores_gemma":[0.9998016,0.0000352916,0.00009848991,0.00001367922,0.0000213954,0.00002955768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03783244,0.004003809,0.3728973,0.0009449161,0.001161655,0.0009288256,0.0004304336,0.001215514,0.2680899,0.0005361514,0.001804708,0.3101544],"study_design_scores_gemma":[0.0001283992,0.004461639,0.98016,0.00004378937,0.000230353,0.0002148819,0.000073376,0.0007669302,0.01211335,0.0001821527,0.001618381,0.000006792694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967797,0.002297018,0.0001369745,0.00006918219,0.00001699548,0.000008714731,0.00006350059,0.00001356874,0.0006143603],"genre_scores_gemma":[0.9982502,0.0008453713,0.0002573294,0.00004400952,0.000019164,0.000008013093,0.00007922749,0.000002902812,0.0004938376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008300747,"threshold_uncertainty_score":0.002776921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173434847943091,"score_gpt":0.2955447035139922,"score_spread":0.2738103550345613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}