{"id":"W4401764025","doi":"10.61186/nl.3.2.39","title":"Metformin attenuates white matter microstructural changes in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Neurology Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Metformin; White matter; White (mutation); Medicine; Internal medicine; Cardiology; Endocrinology; Chemistry; Diabetes mellitus; Magnetic resonance imaging; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006614973,0.0002198872,0.0002444148,0.0003174531,0.00004413636,0.00003881567,0.00009951415,0.00006676627,0.0006460236],"category_scores_gemma":[0.00001116262,0.0001723894,0.0001061758,0.0002122323,0.0001850959,0.000106803,0.00006713501,0.0003434614,0.0008743083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002457671,"about_ca_system_score_gemma":0.00006074193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003404024,"about_ca_topic_score_gemma":0.00002505312,"domain_scores_codex":[0.9985203,0.00008323086,0.0001601448,0.0004777573,0.0002050096,0.0005535853],"domain_scores_gemma":[0.9992972,0.0000726434,0.0000204433,0.0002756475,0.00001645284,0.0003176291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009637094,0.00008326591,0.9550864,0.00008398652,0.00174496,0.01569513,0.0001191739,0.000004052807,0.00259062,0.0000137727,0.02174692,0.001868034],"study_design_scores_gemma":[0.001281049,0.0002418433,0.9919149,0.0000569843,0.0008283596,0.0004046558,0.000008000895,0.0002418643,0.001007154,0.0000904465,0.003717917,0.0002067723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590825,0.008537029,0.000001247676,0.1314973,0.0002572876,0.0003820031,0.00005086373,0.00008138012,0.0001104519],"genre_scores_gemma":[0.9687205,0.00008326989,0.00004271397,0.03068522,0.000178598,0.00009164215,0.000119447,0.00004335877,0.00003523236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1096381,"threshold_uncertainty_score":0.9999036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173434847943091,"score_gpt":0.2955447035139922,"score_spread":0.2738103550345613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}