{"id":"W4401797928","doi":"10.1038/s41417-024-00824-1","title":"Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification","year":2024,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tobacco Research Unit; Princess Margaret Cancer Centre; University of British Columbia; University Health Network; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Centrosome; Biology; Mitosis; Genome instability; Cancer research; Spindle pole body; Cell biology; Genetics; Cancer; Neuroscience; Spindle apparatus; Cell division; Cell; Cell cycle; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373038,0.0001047479,0.0001099363,0.00004738384,0.00002313616,0.00001967932,0.0001029947,0.00006636287,0.00001964284],"category_scores_gemma":[0.000006215831,0.00009048069,0.00004074476,0.000180368,0.00006915318,0.000006637686,0.00001110448,0.00006353332,0.000001678046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001346349,"about_ca_system_score_gemma":0.000308457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224842,"about_ca_topic_score_gemma":0.0002050269,"domain_scores_codex":[0.9992113,0.00004612313,0.0002026012,0.0003248919,0.00008264638,0.0001324453],"domain_scores_gemma":[0.9995815,0.000007391662,0.00006986698,0.0002336429,0.0000789347,0.00002868031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096347,0.00002792525,0.002432273,0.00004349448,0.00007307452,6.930914e-7,0.0005699284,0.00169046,0.9868596,0.0001305234,0.00007669353,0.007885702],"study_design_scores_gemma":[0.0004223969,0.0001163237,0.004964527,0.00002941885,0.00001146304,0.00000222323,0.0001000203,0.001164189,0.9904839,0.0001552051,0.002425136,0.0001251413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825293,0.01159238,0.005119221,0.0001550677,0.0001390911,0.0003314223,0.00007855846,0.00001024346,0.00004472665],"genre_scores_gemma":[0.9922785,0.006939221,0.00007566284,0.0001030114,0.00008973984,0.0001739903,0.0001191705,0.00001957878,0.0002011937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009749144,"threshold_uncertainty_score":0.3689696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009323583993270703,"score_gpt":0.2992183627503715,"score_spread":0.2898947787571008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}