{"id":"W4401805383","doi":"10.1200/po.24.00031","title":"Kinetic Profiling of <i>RAS</i> Mutations With Circulating Tumor DNA in the Canadian Cancer Trials Group CO.26 Trial Suggests the Loss of <i>RAS</i> Mutations in Neo-<i>RAS</i>-Wildtype Metastatic Colorectal Cancer Is Transient","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; Cetuximab; Medicine; Internal medicine; Hazard ratio; Colorectal cancer; Panitumumab; Oncology; HRAS; Mutation; Cancer; Cancer research; Biology; Genetics; Gene; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001939714,0.0002667978,0.0006649589,0.0002568177,0.0001366492,0.00005764077,0.0003752966,0.0001783142,0.00006553918],"category_scores_gemma":[0.0006925474,0.0001792399,0.0001909068,0.0007275136,0.000317036,0.00001398109,0.00004229712,0.0003371001,0.000002103001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163407,"about_ca_system_score_gemma":0.00344377,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.03936238,"about_ca_topic_score_gemma":0.5090942,"domain_scores_codex":[0.9968557,0.0006985559,0.001154732,0.0005227926,0.0003385798,0.0004295747],"domain_scores_gemma":[0.9971153,0.001846424,0.0003966395,0.0003343476,0.0002003319,0.0001069286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02160538,0.002013499,0.01926193,0.0007794527,0.001393907,0.0006434456,0.02715857,0.1150537,0.7452477,0.002774594,0.007571335,0.05649649],"study_design_scores_gemma":[0.1210647,0.02113033,0.05771754,0.002896694,0.004257705,0.0008115239,0.01305657,0.02278532,0.5889306,0.006518038,0.1571513,0.003679649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905322,0.003055931,0.0002836843,0.001826579,0.0006967763,0.002376708,0.0008420848,0.000008737396,0.00037733],"genre_scores_gemma":[0.9965917,0.0005981713,0.0006045765,0.0007496385,0.0002274267,0.001000654,0.0001665252,0.00004728558,0.000013963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4697319,"threshold_uncertainty_score":0.9670346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053604801330025,"score_gpt":0.3476975458351543,"score_spread":0.3171614978218541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}