{"id":"W4401805383","doi":"10.1200/po.24.00031","title":"Kinetic Profiling of <i>RAS</i> Mutations With Circulating Tumor DNA in the Canadian Cancer Trials Group CO.26 Trial Suggests the Loss of <i>RAS</i> Mutations in Neo-<i>RAS</i>-Wildtype Metastatic Colorectal Cancer Is Transient","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; Cetuximab; Medicine; Internal medicine; Hazard ratio; Colorectal cancer; Panitumumab; Oncology; HRAS; Mutation; Cancer; Cancer research; Biology; Genetics; Gene; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001592853,0.0002712469,0.0004996922,0.0001834614,0.0003232543,0.0005607525,0.0003047426,0.0002596373,0.001842471],"category_scores_gemma":[0.001366485,0.0001381574,0.0002776146,0.0002434502,0.0004328722,0.0002607238,0.0001207679,0.0008253668,0.0002075959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00162412,"about_ca_system_score_gemma":0.001423609,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02171679,"about_ca_topic_score_gemma":0.07403364,"domain_scores_codex":[0.9992377,0.0002029653,0.00002816361,0.0001510723,0.0002523524,0.0001278226],"domain_scores_gemma":[0.9987254,0.0002568937,0.0004358994,0.00009592398,0.0001712421,0.0003147236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1322293,0.003195959,0.5785557,0.0005926799,0.001030338,0.0001713547,0.0003212253,0.001823502,0.1109228,0.0006318532,0.008122635,0.1624026],"study_design_scores_gemma":[0.007858716,0.05095411,0.8965231,0.00005751267,0.001202766,0.0006504184,0.000131486,0.004199927,0.0292189,0.0002471461,0.00890285,0.00005306487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922181,0.001990626,0.0003367001,0.0004213955,0.00002660564,0.000146616,0.0005340359,0.00003351047,0.004292331],"genre_scores_gemma":[0.9980944,0.0002243905,0.0002761004,0.0002052416,0.00001660938,0.00002753211,0.0003723344,0.000007508643,0.0007759367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9782832,"threshold_uncertainty_score":0.04318082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053604801330025,"score_gpt":0.3476975458351543,"score_spread":0.3171614978218541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}