{"id":"W4401806042","doi":"10.1038/s41392-024-01930-0","title":"Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Guangzhou Municipal Science and Technology Project; Peking University; National Natural Science Foundation of China","keywords":"Adipogenesis; Annexin A1; Adipocyte; Adipose tissue; Cell biology; Cancer research; Internal medicine; Biology; Endocrinology; Chemistry; Annexin; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690784,0.0001675129,0.0001259196,0.0000791063,0.0001194051,0.0000692914,0.00003998859,0.0001191761,0.0001145269],"category_scores_gemma":[0.000002209016,0.0001438862,0.00005233855,0.0001196791,0.0000715674,0.00001051241,0.00001647323,0.00007662219,0.000002635187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005360889,"about_ca_system_score_gemma":0.00002539645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002111933,"about_ca_topic_score_gemma":0.00001487787,"domain_scores_codex":[0.9991381,0.00005973406,0.0001343308,0.0004152349,0.0000793103,0.0001733406],"domain_scores_gemma":[0.9997177,0.000006133447,0.00001516824,0.00009598483,0.00002488685,0.0001401574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796106,0.00006182873,0.0003584295,0.00003473924,0.00008340836,0.000004664525,0.0003725334,0.000005428948,0.9605979,0.0001836279,0.0001864549,0.03793135],"study_design_scores_gemma":[0.0007259633,0.001171095,0.004714499,0.00004973368,0.00002124509,0.00006184202,0.000215441,0.00004452268,0.8917628,0.001010858,0.09989469,0.0003273264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976211,0.02041684,0.002032576,0.0007984834,0.0001166722,0.0002844502,0.00003606175,0.000031927,0.00007200937],"genre_scores_gemma":[0.9939249,0.004580025,0.0004748261,0.0003017462,0.0002454295,0.00003242067,0.00003253133,0.00002299429,0.0003850877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09970824,"threshold_uncertainty_score":0.5867508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00891411651861381,"score_gpt":0.235291345552783,"score_spread":0.2263772290341692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}