{"id":"W4401806042","doi":"10.1038/s41392-024-01930-0","title":"Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Guangzhou Municipal Science and Technology Project; Peking University; National Natural Science Foundation of China","keywords":"Adipogenesis; Annexin A1; Adipocyte; Adipose tissue; Cell biology; Cancer research; Internal medicine; Biology; Endocrinology; Chemistry; Annexin; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021436,0.0002773286,0.0002500182,0.0002828937,0.0001933366,0.0002168197,0.0002490145,0.0003074278,0.003603269],"category_scores_gemma":[0.00008566736,0.0001161355,0.0003264196,0.000151402,0.0001526101,0.0002121785,0.0002550648,0.0007793505,0.0006878184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192404,"about_ca_system_score_gemma":0.0002366901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003752774,"about_ca_topic_score_gemma":0.0005432091,"domain_scores_codex":[0.999918,0.00001152095,0.000005674766,0.00001572164,0.00002646957,0.00002263706],"domain_scores_gemma":[0.9999622,0.000004653119,0.000007423114,0.000003195493,0.000006814932,0.00001576461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007362688,0.0001987903,0.0007955086,0.0002558765,0.00003866514,0.0001221488,0.00001629621,0.0003641908,0.9785023,0.0006653861,0.001001824,0.01730282],"study_design_scores_gemma":[0.0004024247,0.00141714,0.008647655,0.00003632875,0.00009297384,0.001125071,0.00005549223,0.00338246,0.9394447,0.0007918151,0.04458301,0.00002101508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939897,0.03070819,0.01699741,0.001347558,0.0002999529,0.0001782907,0.0008723913,0.0005841783,0.009114932],"genre_scores_gemma":[0.9750113,0.007426727,0.005730308,0.0004178253,0.00005436575,0.00008602891,0.001220356,0.00002677787,0.01002629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003603269,"threshold_uncertainty_score":0.01205415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00891411651861381,"score_gpt":0.235291345552783,"score_spread":0.2263772290341692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}