{"id":"W4401812927","doi":"10.1042/bcj20230230","title":"Regulation of PARP1/2 and the tankyrases: emerging parallels","year":2024,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"PARP1; Allosteric regulation; Biology; Effector; Poly ADP ribose polymerase; Function (biology); Parallels; Cell biology; DNA damage; Computational biology; Enzyme; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005163526,0.000224723,0.00107047,0.0001239685,0.00004976339,0.00003666714,0.0001091229,0.0002110098,0.0001693632],"category_scores_gemma":[0.0001041585,0.0001152838,0.0005198472,0.0002181877,0.0002921941,0.00002742695,0.00004362381,0.0007144681,0.00001362115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001077429,"about_ca_system_score_gemma":0.0002474634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000115839,"about_ca_topic_score_gemma":3.345891e-8,"domain_scores_codex":[0.9984403,0.000114172,0.000764236,0.0001931254,0.0003337325,0.000154396],"domain_scores_gemma":[0.9990119,0.0001648872,0.0004122018,0.0002101172,0.00008092747,0.0001199252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003789068,0.00007045272,0.00000333801,0.02336906,0.001465095,0.00006063294,0.0002262202,2.942674e-7,0.001215622,0.001588759,0.093828,0.8777936],"study_design_scores_gemma":[0.001199023,0.00003967243,0.000001563855,0.03194017,0.002218594,0.002976398,0.00001889945,0.00001108492,0.0002616803,0.001467783,0.9597329,0.0001321823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006174484,0.9980313,0.00009514581,0.0007219117,0.0002647147,0.0003540707,0.0000162556,0.0000168109,0.0004380257],"genre_scores_gemma":[0.0003865241,0.997723,0.0003168187,0.0001170422,0.001125269,0.00002762679,0.00002281574,0.00003442136,0.0002464601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8776615,"threshold_uncertainty_score":0.4701138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05251421634566076,"score_gpt":0.3994840045239353,"score_spread":0.3469697881782745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}