{"id":"W4401826163","doi":"10.1212/wnl.0000000000209744","title":"Sex-Dependent Effects of Cardiometabolic Health and <i>APOE4</i> on Brain Age","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Helse Sør-Øst RHF; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Economic and Social Research Council; University College London Hospitals NHS Foundation Trust; European Commission; Norges Forskningsråd; Age UK; UK Dementia Research Institute; National Institute for Health and Care Research; Alzheimer's Society; California State University, Bakersfield; Brain Research UK; Alzheimer's Association; National Science Foundation","keywords":"Medicine; Cardiovascular health; Demography; Gerontology; Psychology; Internal medicine; Disease; Sociology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004074319,0.0002551385,0.0001762342,0.0003400096,0.0001545715,0.0003825223,0.0001938404,0.0002507793,0.003034856],"category_scores_gemma":[0.001128303,0.0001417878,0.0003346064,0.0002455621,0.0002420447,0.0002624594,0.0002327578,0.0003101451,0.0003256248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190052,"about_ca_system_score_gemma":0.0002213256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001463816,"about_ca_topic_score_gemma":0.002688001,"domain_scores_codex":[0.9998381,0.00005586887,0.000008211443,0.00003640182,0.00001661547,0.00004483175],"domain_scores_gemma":[0.9990877,0.0002388914,0.0003214877,0.00009220472,0.00006010482,0.0001995679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008410525,0.0003978967,0.9566143,0.0000403232,0.0003911162,0.0003491495,0.0003431243,0.0001023656,0.01381229,0.0002415676,0.0002445312,0.01905282],"study_design_scores_gemma":[0.000009001107,0.0004081524,0.9985451,0.000003483293,0.0000559813,0.0001093539,0.00008034636,0.00006649687,0.0004472008,0.00007386185,0.0001984475,0.000002676037],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976088,0.0007990266,0.00009534429,0.00005610259,0.00001338762,0.000003864649,0.0001960583,0.000003755887,0.001223566],"genre_scores_gemma":[0.9980044,0.0002289868,0.0001149046,0.00003663303,0.00001532619,0.000005791689,0.0001328452,0.000004910489,0.001456151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003034856,"threshold_uncertainty_score":0.01015264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007047411158006372,"score_gpt":0.2581075216585964,"score_spread":0.25106011050059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}