{"id":"W4401827704","doi":"10.1101/2024.08.21.608995","title":"Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer’s disease","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Concordia University","funders":"","keywords":"Apolipoprotein E; Family history; Disease; White matter; Affect (linguistics); Glycated hemoglobin; Psychology; Cognition; Risk factor; Blood pressure; Medicine; Internal medicine; Gerontology; Endocrinology; Neuroscience; Type 2 diabetes; Diabetes mellitus; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003092469,0.0003200629,0.0002453494,0.0005375943,0.0001920829,0.0004279669,0.0001590103,0.0003351549,0.003510814],"category_scores_gemma":[0.001026902,0.0001349701,0.0003061476,0.000390241,0.0001499499,0.0001710549,0.0002488792,0.0002691228,0.0002407693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008347733,"about_ca_system_score_gemma":0.0001768183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445835,"about_ca_topic_score_gemma":0.001642125,"domain_scores_codex":[0.9998758,0.00002503738,0.00001070043,0.00004707527,0.00001770153,0.00002356422],"domain_scores_gemma":[0.9995364,0.00008350179,0.0001868329,0.00005744059,0.00004973971,0.00008613484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006663276,0.00005345641,0.9904153,0.00001543178,0.0001859396,0.0002976253,0.0001121496,0.00004756638,0.00330949,0.00004769803,0.0001434896,0.004705502],"study_design_scores_gemma":[0.00000411042,0.00005509709,0.9989811,0.000003148087,0.00004064189,0.0003000153,0.00005603304,0.000113228,0.000274766,0.00008886636,0.00008110596,0.000001891554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988954,0.0003186965,0.0001313546,0.00005034404,0.000008986834,0.000001564267,0.0001845246,0.00000432652,0.0004046942],"genre_scores_gemma":[0.99918,0.00009344091,0.00009938199,0.00001664446,0.0000143035,0.000001888453,0.0001253362,0.000003091696,0.0004658187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003510814,"threshold_uncertainty_score":0.0117448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311881122111306,"score_gpt":0.2727561212567035,"score_spread":0.2296373100355904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}