{"id":"W4401833666","doi":"10.1002/ange.202410353","title":"Rapid Thermal Drying Synthesis of Nonthiolated Spherical Nucleic Acids with Stability Rivaling Thiolated DNA","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Key Technologies Research and Development Program; Natural Sciences and Engineering Research Council of Canada; National Key Research and Development Program of China; China Scholarship Council; University of Waterloo","keywords":"Nucleic acid; Thermal stability; DNA; Chemistry; Chemical engineering; Combinatorial chemistry; Nanotechnology; Materials science; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002421056,0.0002905611,0.0001465577,0.0001830769,0.0001096011,0.0001862803,0.0001985127,0.000233522,0.0005712768],"category_scores_gemma":[0.0003459792,0.0002130086,0.0001977755,0.000123545,0.0001961293,0.0001967079,0.00020049,0.0002959396,0.0003651736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001738825,"about_ca_system_score_gemma":0.0002142023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003433347,"about_ca_topic_score_gemma":0.0009096534,"domain_scores_codex":[0.9998437,0.00002189822,0.00001581901,0.00003848412,0.00006447962,0.00001558371],"domain_scores_gemma":[0.9997765,0.00004147174,0.00005662658,0.0000283854,0.0000726135,0.00002442694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004931845,0.000002064477,0.00001243917,0.00001006566,0.000001320692,0.000006815259,0.000006012501,0.00004894527,0.999159,0.00004972453,0.000006761145,0.0006920116],"study_design_scores_gemma":[0.000001621478,0.00003853486,0.0001029591,6.739322e-7,0.000001901211,0.00002286983,0.000002809658,0.0005511246,0.9987363,0.00001010112,0.000528898,0.000002125054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944495,0.00121139,0.05154582,0.00008452182,0.00008152777,0.00009345164,0.0001371728,0.0002941275,0.002056987],"genre_scores_gemma":[0.9512016,0.000787772,0.04414521,0.00005228653,0.00001470916,0.00005572298,0.0001753727,0.000070325,0.003497016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005712768,"threshold_uncertainty_score":0.001911104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233715417487899,"score_gpt":0.2231400741532965,"score_spread":0.2108029199784175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}