{"id":"W4401834545","doi":"10.1126/sciimmunol.adh0545","title":"Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain","year":2024,"lang":"en","type":"article","venue":"Science Immunology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Heart Foundation","keywords":"Substance P; Degranulation; Mast cell; Serotonin; Hyperalgesia; Medicine; Neurogenic inflammation; Pharmacology; Histamine; Neuropeptide; Receptor; Nociception; Anesthesia; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005714865,0.00009243788,0.0001921236,0.0001614596,0.00009855364,0.00002034809,0.00008596248,0.00006286847,0.00009788465],"category_scores_gemma":[0.0005354157,0.00006761762,0.00002415563,0.0003680408,0.001139386,0.0001041532,0.00006882224,0.0001264041,0.00002442052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000469876,"about_ca_system_score_gemma":0.00023377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002755364,"about_ca_topic_score_gemma":0.000003137249,"domain_scores_codex":[0.9991039,0.0000749669,0.0001322793,0.0002864626,0.0001576914,0.0002447133],"domain_scores_gemma":[0.9994517,0.0001893814,0.0000204102,0.0001525087,0.0001104828,0.00007552334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004925312,0.0001046521,0.00388241,0.00006225744,0.00003246257,0.0002055097,0.001152112,3.18315e-7,0.9744052,0.01523338,0.00004751786,0.004824935],"study_design_scores_gemma":[0.001292151,0.003098357,0.06200571,0.0004108916,0.00008926676,0.0002469415,0.006003374,0.002552554,0.920068,0.002942887,0.001054653,0.0002351741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907258,0.003554081,0.0005854291,0.003917944,0.0003319273,0.0002092763,0.000007723111,0.00003890604,0.0006289662],"genre_scores_gemma":[0.9967121,0.00008386567,0.002727907,0.0002961363,0.000009068021,0.00001862934,0.000002144397,0.00000678341,0.00014335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0581233,"threshold_uncertainty_score":0.4198113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0094777561280523,"score_gpt":0.29074733554157,"score_spread":0.2812695794135177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}