{"id":"W4401834545","doi":"10.1126/sciimmunol.adh0545","title":"Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain","year":2024,"lang":"en","type":"article","venue":"Science Immunology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Heart Foundation","keywords":"Substance P; Degranulation; Mast cell; Serotonin; Hyperalgesia; Medicine; Neurogenic inflammation; Pharmacology; Histamine; Neuropeptide; Receptor; Nociception; Anesthesia; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148959,0.0002395575,0.0001956961,0.0002077975,0.0001514426,0.0002255152,0.0001356458,0.000297487,0.002013058],"category_scores_gemma":[0.000153094,0.0000827384,0.0001771347,0.0001487227,0.0002087137,0.000220768,0.0002254671,0.0003684152,0.0002805387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001250231,"about_ca_system_score_gemma":0.0001648941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343466,"about_ca_topic_score_gemma":0.000353672,"domain_scores_codex":[0.9999063,0.00001937883,0.000006927451,0.00001157961,0.00002740017,0.00002845335],"domain_scores_gemma":[0.9998819,0.00001882043,0.00005330007,0.000006866632,0.00001423594,0.00002498589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000881259,0.00008016024,0.005378374,0.0003257859,0.00003186171,0.001106774,0.00005387624,0.00005695493,0.966235,0.0003014077,0.0002278584,0.02532055],"study_design_scores_gemma":[0.0001619105,0.005581505,0.2502751,0.0001499859,0.0002210462,0.009711552,0.0004300699,0.0008453349,0.7073625,0.001299519,0.02392742,0.00003398704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9247382,0.06578622,0.004227336,0.0006150682,0.0001407241,0.00008324003,0.0004077172,0.00008986062,0.003911696],"genre_scores_gemma":[0.9854613,0.01119634,0.001000413,0.0001071532,0.00007373094,0.00002507495,0.0002069743,0.000005300376,0.001923629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013058,"threshold_uncertainty_score":0.006734371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0094777561280523,"score_gpt":0.29074733554157,"score_spread":0.2812695794135177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}