{"id":"W4401843338","doi":"10.1093/cid/ciae410","title":"CLOVER (CLOstridium difficile Vaccine Efficacy tRial) Study: A Phase 3, Randomized Trial Investigating the Efficacy and Safety of a Detoxified Toxin A/B Vaccine in Adults 50 Years and Older at Increased Risk of <i>Clostridioides difficile</i> Infection","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada)","funders":"Pfizer","keywords":"Medicine; Placebo; Tolerability; Clinical endpoint; Internal medicine; Adverse effect; Post-hoc analysis; Randomized controlled trial; Clostridioides","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001299203,0.0009853748,0.001511817,0.0002314098,0.0003019725,0.0007231537,0.0005249365,0.001086844,0.003177342],"category_scores_gemma":[0.001140621,0.0004040953,0.0009527163,0.0002268674,0.0005511306,0.0004500238,0.0002724363,0.001529045,0.0004784092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004719479,"about_ca_system_score_gemma":0.0009041697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241735,"about_ca_topic_score_gemma":0.003209941,"domain_scores_codex":[0.9995202,0.0002960421,0.00001906013,0.00006308241,0.00004009804,0.00006150228],"domain_scores_gemma":[0.9993864,0.0001196869,0.0002156187,0.00003435607,0.00004234889,0.0002015697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9609372,0.00604771,0.00307517,0.000779254,0.001000343,0.0001210134,0.00007300106,0.0003647866,0.007840236,0.0001296684,0.001319385,0.01831218],"study_design_scores_gemma":[0.8883515,0.09816424,0.0105928,0.00008087142,0.0006339256,0.0001359194,0.00003113628,0.0003444338,0.0006411498,0.00008081861,0.000929738,0.00001354837],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928553,0.002891685,0.0002628992,0.0003662564,0.0001130828,0.00143659,0.0006795041,0.00006889293,0.001325919],"genre_scores_gemma":[0.9904261,0.002064669,0.001231143,0.00121079,0.0001672655,0.002024341,0.001303713,0.00001317163,0.001558875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003177342,"threshold_uncertainty_score":0.0106293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02599235037296579,"score_gpt":0.3582747018806317,"score_spread":0.3322823515076659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}