{"id":"W4401844652","doi":"10.1002/mco2.694","title":"Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies","year":2024,"lang":"en","type":"review","venue":"MedComm","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Targeted therapy; Medicine; Tyrosine-kinase inhibitor; Drug resistance; Acquired resistance; Mechanism (biology); Tumor microenvironment; Cancer; Cancer research; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054593,0.000290264,0.001058236,0.000193464,0.00004467488,0.00004113052,0.00006976917,0.0001237441,0.00004321833],"category_scores_gemma":[0.00001944174,0.0001904792,0.0001756796,0.0003173068,0.000034578,0.00004798974,0.00004470499,0.0001819073,0.00001515118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308845,"about_ca_system_score_gemma":0.0003714347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004044174,"about_ca_topic_score_gemma":0.00004414616,"domain_scores_codex":[0.9989177,0.00004209801,0.0003744177,0.0003096953,0.0001922177,0.0001638919],"domain_scores_gemma":[0.9993432,0.00005888821,0.0001071682,0.0003210876,0.0000558308,0.0001138663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005654635,0.000177144,0.000003394341,0.03260013,0.001138441,0.0001283926,0.0009606925,2.318297e-7,0.000219537,0.01145639,0.007660034,0.9455991],"study_design_scores_gemma":[0.0004922599,0.0002156876,0.00001616364,0.02312589,0.001842728,0.00001511833,0.000169438,8.251182e-7,0.00013656,0.0009505494,0.9728531,0.0001816339],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008586031,0.9965952,0.0001696918,0.0002727868,0.0002866565,0.0009837244,0.0001366222,0.00005209153,0.001417359],"genre_scores_gemma":[0.001285686,0.9938294,0.002092429,0.00009937236,0.00009719743,0.0001613333,0.0001225253,0.00005970899,0.002252406],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9651931,"threshold_uncertainty_score":0.7767517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239765128279061,"score_gpt":0.3760929962378824,"score_spread":0.3336953449550918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}