{"id":"W4401844652","doi":"10.1002/mco2.694","title":"Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies","year":2024,"lang":"en","type":"review","venue":"MedComm","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Targeted therapy; Medicine; Tyrosine-kinase inhibitor; Drug resistance; Acquired resistance; Mechanism (biology); Tumor microenvironment; Cancer; Cancer research; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004107266,0.0005922057,0.0008582957,0.001789443,0.0002484214,0.0008144788,0.0006360409,0.0008283802,0.003376703],"category_scores_gemma":[0.0003976928,0.0002406342,0.0004965535,0.0009815492,0.0003558716,0.0008868919,0.0004985428,0.001320127,0.001443504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006053746,"about_ca_system_score_gemma":0.0007272934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007017212,"about_ca_topic_score_gemma":0.001525689,"domain_scores_codex":[0.9998228,0.00003101107,0.00001842082,0.0000289023,0.00007232899,0.00002647225],"domain_scores_gemma":[0.9998858,0.00004808937,0.00001854053,0.00000438866,0.00003279122,0.00001033104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008100705,0.0001080397,0.0002734079,0.02119941,0.0001110061,0.0003321913,0.0001165535,0.001014216,0.009121106,0.01396949,0.03761571,0.9160579],"study_design_scores_gemma":[0.00001938361,0.0001219134,0.0005898246,0.001965118,0.00008029534,0.001087514,0.00005393098,0.00026307,0.002044889,0.002680107,0.9910748,0.00001924805],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005617469,0.995381,0.0003643809,0.0006661008,0.0002072124,0.0000138453,0.00004662823,0.00001843896,0.002740647],"genre_scores_gemma":[0.002675166,0.9951596,0.0002611738,0.0003148917,0.0001395477,0.00001799379,0.00005369173,0.000002322018,0.001375653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003376703,"threshold_uncertainty_score":0.01129615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239765128279061,"score_gpt":0.3760929962378824,"score_spread":0.3336953449550918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}