{"id":"W4401856446","doi":"10.1101/2024.08.19.608704","title":"The Brain Interactome of a Permissive Prion Replication Substrate","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Interactome; Prion protein; Biology; Cell biology; Protein–protein interaction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007244814,0.0002476304,0.0001417456,0.0004231153,0.0002028991,0.0003462693,0.0001421349,0.0002296748,0.001689799],"category_scores_gemma":[0.0001035146,0.000116456,0.0001414329,0.0001485749,0.0001659002,0.0001224532,0.0002136585,0.0002983419,0.0004065467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717282,"about_ca_system_score_gemma":0.00008144597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533537,"about_ca_topic_score_gemma":0.0009484103,"domain_scores_codex":[0.9999385,0.000007212152,0.000002906745,0.0000214831,0.00001486775,0.00001506994],"domain_scores_gemma":[0.9998974,0.00002098102,0.00003326431,0.00001036097,0.00001237576,0.00002561808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007087531,0.000005767325,0.0007450702,0.00001068033,0.000006629857,0.0001472802,0.00001590907,0.00002024689,0.998542,0.00006334962,0.00003089841,0.0003413857],"study_design_scores_gemma":[0.00001164256,0.0002141993,0.09413207,0.00001961292,0.00004903886,0.003050969,0.0002504764,0.002307335,0.8966345,0.000392636,0.002924375,0.00001307726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977431,0.000237082,0.0009314659,0.00003080614,0.000004425057,0.000002848872,0.0003118962,0.0000176724,0.0007206959],"genre_scores_gemma":[0.995539,0.0001819407,0.001472073,0.00002920187,0.000004522911,0.000008373763,0.0009571393,0.00002172433,0.001785966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689799,"threshold_uncertainty_score":0.005652905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038633397442891,"score_gpt":0.2522095119316251,"score_spread":0.2418231779571962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}