{"id":"W4401865484","doi":"10.1016/j.ijid.2024.107222","title":"Suppressed HIV antibody responses following exposure to antiretrovirals—evidence from PrEP randomized trials and early antiretroviral treatment initiation studies","year":2024,"lang":"en","type":"article","venue":"International Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Grifols; National Heart, Lung, and Blood Institute; U.S. Department of Defense; Gilead Sciences; ViiV Healthcare; Henry M. Jackson Foundation; Merck","keywords":"Medicine; Human immunodeficiency virus (HIV); Antibody; Virology; Immunology; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05399671,0.001065267,0.004124323,0.00118342,0.000479538,0.002639803,0.001955109,0.002811095,0.008053927],"category_scores_gemma":[0.1159456,0.0008669457,0.007881806,0.001869058,0.001786787,0.002230519,0.001022136,0.002864913,0.0006703492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007195416,"about_ca_system_score_gemma":0.001530188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005697563,"about_ca_topic_score_gemma":0.0008632841,"domain_scores_codex":[0.9493419,0.03662703,0.007234792,0.002347694,0.003758712,0.0006898807],"domain_scores_gemma":[0.7913538,0.1573535,0.03720485,0.006001442,0.006099934,0.001986559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3343611,0.00236921,0.04929076,0.1341018,0.1816037,0.0004971577,0.0005897165,0.001165216,0.001581263,0.00183667,0.006297819,0.2863056],"study_design_scores_gemma":[0.2302163,0.08622102,0.1989342,0.08066521,0.3303007,0.001785726,0.000627928,0.001596393,0.003082319,0.005176685,0.06112724,0.0002663736],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1648466,0.805507,0.004110427,0.006352338,0.002703089,0.003986966,0.003262986,0.00009571461,0.009134903],"genre_scores_gemma":[0.8055141,0.1724669,0.006149375,0.007561838,0.002747495,0.002307055,0.002247392,0.00007271946,0.0009331049],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.05399671,"threshold_uncertainty_score":0.2855653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04547011764088921,"score_gpt":0.3900306473989397,"score_spread":0.3445605297580505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}