{"id":"W4401868923","doi":"10.1016/j.bpj.2024.08.017","title":"The minimal membrane requirements for BAX-induced pore opening upon exposure to oxidative stress","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Metal-Organic Frameworks: Synthesis and Applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Umeå Universitet; Univerzita Karlova v Praze; Grantová Agentura České Republiky; European Commission; Sunnybrook Research Institute","keywords":"Oxidative stress; Biophysics; Membrane; Oxidative phosphorylation; Chemistry; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002520263,0.0001888848,0.0002114091,0.00003054406,0.0004929645,0.0005180705,0.0004851187,0.0001092583,0.0003172249],"category_scores_gemma":[0.0001853264,0.0001232475,0.000212869,0.0001852837,0.0000315871,0.0001382105,0.00009323526,0.0004252594,0.00006337629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009481113,"about_ca_system_score_gemma":0.00007454016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003833679,"about_ca_topic_score_gemma":0.00000216832,"domain_scores_codex":[0.9985951,0.00002951592,0.000371448,0.0003071203,0.0003450397,0.0003517638],"domain_scores_gemma":[0.9988488,0.0004315298,0.0001089424,0.0002952814,0.00009759416,0.0002178599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005264104,0.00007576575,0.000004284961,0.00003716202,0.0001337585,0.00001111588,0.0001821598,0.000005868747,0.9673722,0.004877233,0.0009923454,0.02625542],"study_design_scores_gemma":[0.000195765,0.00008683198,0.00003202019,0.0003135593,0.00008192493,0.00002220695,0.0006064797,0.0007550243,0.972977,0.0004575291,0.02428223,0.0001894106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908639,0.0001358485,0.003110614,0.004115073,0.0003686877,0.000215257,0.00009063012,0.0000572249,0.0010428],"genre_scores_gemma":[0.9958088,0.00002757693,0.001460504,0.00007065422,0.001824728,0.00008765318,0.00001497423,0.00003508456,0.0006700678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02606601,"threshold_uncertainty_score":0.5025887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610629191403098,"score_gpt":0.3040046739078646,"score_spread":0.2678983819938336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}